如何在弥漫性大B细胞淋巴瘤中将CD19特异性嵌合抗原受体T细胞与其他CD19靶向药物整合？

IF 3.3 4区医学 Q2 HEMATOLOGY

Hematological Oncology Pub Date : 2023-11-08 DOI:10.1002/hon.3237

Carmen de Ramon Ortiz, Sisi Wang, Anastasios Stathis, Francesco Bertoni, Thorsten Zenz, Urban Novak, Federico Simonetta

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引用次数: 0

摘要

大约三分之一的弥漫性大B细胞淋巴瘤（DLBCL）患者在一线化疗免疫治疗后出现复发/难治性（R/R）疾病，在原发性难治性疾病和早期复发的患者中观察到的结果特别差。CD19特异性嵌合抗原受体（CAR）T细胞疗法改变了游戏规则，在几乎一半的R/R DLBCL患者中产生了持久和完全的应答率。其他新兴的CD19靶向疗法包括单克隆抗体、双特异性抗体和靶向抗体-药物偶联物，它们也显示出令人鼓舞的结果。然而，不同的抗CD19靶向剂的时间和测序以及它们如何干扰随后的CAR T细胞治疗仍不清楚。在这篇综述中，我们总结了关键临床试验的结果，以及使用不同CD19靶向批准药物的真实世界系列证据。我们讨论了各种疗法对CD19表达的影响及其对治疗序列的影响。

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How to integrate CD19 specific chimeric antigen receptor T cells with other CD19 targeting agents in diffuse large B-cell lymphoma?

About one third of patients with diffuse large B-cell lymphoma (DLBCL) have a relapsing/refractory (R/R) disease after first line chemo-immunotherapy, with particularly poor outcomes observed in patients with primary refractory disease and early relapse. CD19 specific chimeric antigen receptor (CAR) T cell therapy is a game changer that results in durable and complete response rates in almost half of the patients with R/R DLBCL. Other emerging CD19-targeting therapies include monoclonal antibodies, bispecific antibodies and targeting antibody-drug conjugates, which also show encouraging results. However, the timing and sequencing of different anti-CD19-targeting agents and how they might interfere with subsequent CAR T cell treatment is still unclear. In this review, we summarize the results of the pivotal clinical trials as well as evidence from real-world series of the use of different CD19-targeting approved agents. We discuss the effect of various therapies on CD19 expression and its implications for treatment sequencing.

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来源期刊

Hematological Oncology 医学-血液学

CiteScore

4.20

自引率

6.10%

发文量

147

审稿时长

>12 weeks

期刊介绍： Hematological Oncology considers for publication articles dealing with experimental and clinical aspects of neoplastic diseases of the hemopoietic and lymphoid systems and relevant related matters. Translational studies applying basic science to clinical issues are particularly welcomed. Manuscripts dealing with the following areas are encouraged: -Clinical practice and management of hematological neoplasia, including: acute and chronic leukemias, malignant lymphomas, myeloproliferative disorders -Diagnostic investigations, including imaging and laboratory assays -Epidemiology, pathology and pathobiology of hematological neoplasia of hematological diseases -Therapeutic issues including Phase 1, 2 or 3 trials as well as allogeneic and autologous stem cell transplantation studies -Aspects of the cell biology, molecular biology, molecular genetics and cytogenetics of normal or diseased hematopoeisis and lymphopoiesis, including stem cells and cytokines and other regulatory systems. Concise, topical review material is welcomed, especially if it makes new concepts and ideas accessible to a wider community. Proposals for review material may be discussed with the Editor-in-Chief. Collections of case material and case reports will be considered only if they have broader scientific or clinical relevance.