妊娠剧吐孕妇血清β-人绒毛膜促性腺激素水平与甲状腺代谢功能的相关性。

IF 1.4 4区 医学 Q4 PHYSIOLOGY
Haiyan Zheng, Qian Wang, Feng Chen
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引用次数: 0

摘要

如前所述,血清β-人绒毛膜促性腺激素(β-hCG)与早期妊娠异常的识别有关。本研究旨在探讨妊娠剧吐孕妇血清β-hCG水平与甲状腺代谢功能的相关性。选择91名HG孕妇作为研究组,根据孕周分为早孕(EP)、孕中期(MP)和孕晚期(LP)组,选择84名正常孕妇作为对照组。两组孕妇均采集静脉血,采用化学发光免疫法测定血清β-hCG水平。采用化学发光微粒免疫测定法检测游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、促甲状腺素受体抗体(TRAb)和甲状腺球蛋白抗体(TgAb)的水平。采用视觉模拟量表(VAS)评分来评估HG的程度。采用Pearson分析法测定血清β-hCG水平与血清FT3、FT4、TSH、TPOAb、TRAb、TgAb以及VAS评分之间的相关性,以及β-hCG、FT3、FTI、TSH,TPOAb,TRAb、GgAb和VAS评分与妊娠期之间的相关性。绘制受试者工作特性(ROC)曲线,以分析甲状腺激素、甲状腺相关抗体和β-hCG水平对HG的诊断价值。与对照组相比,研究组的β-hCG、FT3、FT4、TPOAb、TRAb、TgAb水平和VAS评分较高,TSH水平较低。与EP组相比,MP组和LP组孕妇的β-hCG、FT3、FT4、TPOAb、TRAb、TgAb水平和VAS评分降低,TSH水平升高。HG孕妇血清β-hCG水平与FT3、FT4、TPOAb、TRAb、TgAb和VAS评分呈正相关,与TSH水平呈负相关。HG孕妇血清β-hCG、FT3、FT4、TPOAb、TRAb、TgAb水平和VAS评分与妊娠期呈负相关,TSH水平与妊娠期呈正相关。ROC曲线分析表明,β-hCG和甲状腺功能相关指标对HG的诊断具有较高的临床价值。总之,我们的文章表明,HG孕妇血清β-hCG的表达异常升高,与HG和甲状腺功能亢进的程度密切相关。此外,β-hCG和甲状腺功能相关指标对HG有一定的诊断疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation between serum beta-human chorionic gonadotropin levels and thyroid metabolic function in pregnant women with hyperemesis gravidarum.

As previously demonstrated, serum beta-human chorionic gonadotropin (β-hCG) is linked to identifying early gestational abnormalities. This research was aimed at investigating the correlation between serum β-hCG levels and thyroid metabolic function in pregnant women with hyperemesis gravidarum (HG). Ninety-one pregnant women with HG were selected as the study group and divided into early pregnancy (EP), mid-pregnancy (MP), and late pregnancy (LP) groups according to their gestational weeks, while 84 normal pregnant women were selected as the control group. Venous blood was collected from pregnant women in both groups and serum β-hCG levels were measured by chemiluminescent immunoassay. The levels of free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), thyroid-stimulating hormone receptor antibody (TRAb), and thyroglobulin antibody (TgAb) were tested by chemiluminescent microparticle immunoassay. Visual analog scale (VAS) scores were utilized to assess the degree of HG. Pearson analysis was implemented to measure the correlations between serum β-hCG levels and serum FT3, FT4, TSH, TPOAb, TRAb, TgAb, as well as VAS scores and the correlations between β-hCG, FT3, FT4, TSH, TPOAb, TRAb, TgAb, as well as VAS scores and gestation period. The receiver operating characteristic (ROC) curve was plotted to analyze the diagnostic values of thyroid hormones, thyroid-related antibodies, and β-hCG levels for HG. Versus those in the control group, β-hCG, FT3, FT4, TPOAb, TRAb, TgAb levels, and VAS scores were higher and TSH levels were lower in the study group. Versus those in the EP group, β-hCG, FT3, FT4, TPOAb, TRAb, TgAb levels, and VAS scores of pregnant women in the MP and LP groups were decreased, and TSH levels were increased. Serum β-hCG levels of pregnant women with HG were positively correlated with FT3, FT4, TPOAb, TRAb, TgAb, and VAS scores and negatively correlated with TSH levels. Serum β-hCG, FT3, FT4, TPOAb, TRAb, TgAb levels, and VAS scores of pregnant women with HG had a negative correlation with the gestation period, while TSH levels had a positive correlation with the gestation period. The ROC curve analysis showed that β-hCG and thyroid function-related indicators were of high clinical values in the diagnosis of HG. Collectively, our article suggests that serum β-hCG expression of pregnant women with HG is abnormally elevated and closely related to the degree of HG and hyperthyroidism. In addition, β-hCG and thyroid function-related indicators have certain diagnostic efficacy for HG.

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来源期刊
CiteScore
2.30
自引率
5.60%
发文量
36
审稿时长
6-12 weeks
期刊介绍: Chinese Journal of Physiology is a multidisciplinary open access journal. Chinese Journal of Physiology (CJP) publishes high quality original research papers in physiology and pathophysiology by authors all over the world. CJP welcomes submitted research papers in all aspects of physiology science in the molecular, cellular, tissue and systemic levels. Multidisciplinary sciences with a focus to understand the role of physiology in health and disease are also encouraged. Chinese Journal of Physiology accepts fourfold article types: Original Article, Review Article (Mini-Review included), Short Communication, and Editorial. There is no cost for readers to access the full-text contents of publications.
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