Horatio和Polonius:组织稳态和修复中的固有淋巴细胞。

Q3 Medicine
Intelly S Lee, Steven J Van Dyken
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引用次数: 0

摘要

固有淋巴细胞(ILCs)已成为协调对环境压力和损伤反应的关键组织驻留淋巴细胞。传统上,它们的功能被认为反映了对特定病原体做出反应的适应性淋巴细胞。然而,最近的研究发现,即使在没有感染的情况下,ILCs在维持体内平衡方面也发挥着更重要的作用。ILCs现在被更好地概念化为一种环境变阻器,通过将感觉刺激整合到直接的稳态屏障和修复程序中,在环境挑战期间帮助维持局部组织设置点。在这篇文章中,我们追踪了ILCs的发育起源,讲述了ILCs如何感知危险信号,并使用ILCs在组织回路中作为中央控制器的一般范式描述了它们随后参与的适当修复反应。我们认为,这些相互作用构成了ILC亚群如何维持器官功能和组织稳态的基础,对人类健康具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Both Horatio and Polonius: Innate Lymphoid Cells in Tissue Homeostasis and Repair.

Innate lymphoid cells (ILCs) have emerged as critical tissue-resident lymphocytes that coordinate responses to environmental stress and injury. Traditionally, their function was thought to mirror adaptive lymphocytes that respond to specific pathogens. However, recent work has uncovered a more central role for ILCs in maintaining homeostasis even in the absence of infection. ILCs are now better conceptualized as an environmental rheostat that helps maintain the local tissue setpoint during environmental challenge by integrating sensory stimuli to direct homeostatic barrier and repair programs. In this article, we trace the developmental origins of ILCs, relate how ILCs sense danger signals, and describe their subsequent engagement of appropriate repair responses using a general paradigm of ILCs functioning as central controllers in tissue circuits. We propose that these interactions form the basis for how ILC subsets maintain organ function and organismal homeostasis, with important implications for human health.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
0
审稿时长
4 weeks
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