一碳利用人工生物系统的设计与构建。

Q2 Agricultural and Biological Sciences
生物设计研究(英文) Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI:10.34133/bdr.0021
Wei Zhong, Hailong Li, Yajie Wang
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引用次数: 0

摘要

第三代(3G)生物精炼厂旨在利用微生物细胞工厂或酶系统,以光和电等可再生能源为燃料,从单碳(C1)来源合成增值化学品,如二氧化碳、甲酸盐和甲醇。这项有前景的技术代表着朝着可持续发展迈出了重要一步,有助于解决现代社会面临的一些最紧迫的环境挑战。然而,为了建立与石油行业竞争的工艺,确定C1利用率、目标产品的生产率和产量的最可行途径至关重要。在这篇综述中,我们讨论了过去10年来3G生物精炼厂在构建人工生物系统方面取得的进展。具体而言,我们重点介绍了人工自养微生物工程、串联酶系统和化学-生物杂交系统用于C1利用的代表性工作。我们还展望了这些发展对生物技术的革命性影响。通过利用3G生物炼制的力量,科学家们正在建立一个新的前沿,这可能会彻底改变我们的工业生产方法,并为更可持续的未来铺平道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Design and Construction of Artificial Biological Systems for One-Carbon Utilization.

Design and Construction of Artificial Biological Systems for One-Carbon Utilization.

Design and Construction of Artificial Biological Systems for One-Carbon Utilization.

Design and Construction of Artificial Biological Systems for One-Carbon Utilization.

The third-generation (3G) biorefinery aims to use microbial cell factories or enzymatic systems to synthesize value-added chemicals from one-carbon (C1) sources, such as CO2, formate, and methanol, fueled by renewable energies like light and electricity. This promising technology represents an important step toward sustainable development, which can help address some of the most pressing environmental challenges faced by modern society. However, to establish processes competitive with the petroleum industry, it is crucial to determine the most viable pathways for C1 utilization and productivity and yield of the target products. In this review, we discuss the progresses that have been made in constructing artificial biological systems for 3G biorefineries in the last 10 years. Specifically, we highlight the representative works on the engineering of artificial autotrophic microorganisms, tandem enzymatic systems, and chemo-bio hybrid systems for C1 utilization. We also prospect the revolutionary impact of these developments on biotechnology. By harnessing the power of 3G biorefinery, scientists are establishing a new frontier that could potentially revolutionize our approach to industrial production and pave the way for a more sustainable future.

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来源期刊
CiteScore
3.90
自引率
0.00%
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审稿时长
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