细胞治疗在T2D中的作用。

IF 2.8 3区医学 Q2 UROLOGY & NEPHROLOGY

Seminars in nephrology Pub Date : 2023-05-01 DOI:10.1016/j.semnephrol.2023.151432

Sudipta Ashe PhD , Matthias Hebrok PhD

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引用次数: 0

摘要

2型糖尿病（T2D）已成为影响数百万人健康的全球流行病。T2D是一种复杂的多因素代谢性疾病，其主要特征是胰岛内β细胞的胰岛素分泌受损和外周胰岛素抵抗。在这篇文章中，我们讨论了T2D的现状和风险因素、常规治疗方案和即将到来的策略，包括异基因和异种胰岛移植领域的进展，主要关注干细胞衍生的β细胞和相关技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Role of Cell-Based Therapies in T2D

Type 2 diabetes mellitus (T2D) has become a global epidemic affecting the health of millions of people. T2D is a complex and multifactorial metabolic disease, largely characterized by a combination of impaired insulin secretion from β cells residing within the islets of the pancreas and peripheral insulin resistance. In this article, we discuss the current state and risk factors for T2D, conventional treatment options, and upcoming strategies, including progress in the areas of allogeneic and xenogeneic islet transplantation, with a major focus on stem cell–derived β cells and associated technologies.

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来源期刊

Seminars in nephrology 医学-泌尿学与肾脏学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Seminars in Nephrology is a timely source for the publication of new concepts and research findings relevant to the clinical practice of nephrology. Each issue is an organized compendium of practical information that serves as a lasting reference for nephrologists, internists and physicians in training.