{"title":"秀丽隐杆线虫线粒体动力学的机制和作用。","authors":"Daniel Campbell, Steven Zuryn","doi":"10.1016/j.semcdb.2023.10.006","DOIUrl":null,"url":null,"abstract":"<div><p>If mitochondria are the powerhouses of the cell, then mitochondrial dynamics are the power grid that regulates how that energy output is directed and maintained in response to unique physiological demands. Fission and fusion dynamics are highly regulated processes that fine-tune the mitochondrial networks of cells to enable appropriate responses to intrinsic and extrinsic stimuli, thereby maintaining cellular and organismal homeostasis. These dynamics shape many aspects of an organism’s healthspan including development, longevity, stress resistance, immunity, and response to disease. In this review, we discuss the latest findings regarding the mechanisms and roles of mitochondrial dynamics by focussing on the nematode <em>Caenorhabditis elegans</em>. Whole live-animal studies in <em>C. elegans</em> have enabled a true organismal-level understanding of the impact that mitochondrial dynamics play in homeostasis over a lifetime.</p></div>","PeriodicalId":21735,"journal":{"name":"Seminars in cell & developmental biology","volume":null,"pages":null},"PeriodicalIF":6.2000,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1084952123002033/pdfft?md5=a0d52e7e69a0bc2a8b74d3f6825556d7&pid=1-s2.0-S1084952123002033-main.pdf","citationCount":"0","resultStr":"{\"title\":\"The mechanisms and roles of mitochondrial dynamics in C. elegans\",\"authors\":\"Daniel Campbell, Steven Zuryn\",\"doi\":\"10.1016/j.semcdb.2023.10.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>If mitochondria are the powerhouses of the cell, then mitochondrial dynamics are the power grid that regulates how that energy output is directed and maintained in response to unique physiological demands. Fission and fusion dynamics are highly regulated processes that fine-tune the mitochondrial networks of cells to enable appropriate responses to intrinsic and extrinsic stimuli, thereby maintaining cellular and organismal homeostasis. These dynamics shape many aspects of an organism’s healthspan including development, longevity, stress resistance, immunity, and response to disease. In this review, we discuss the latest findings regarding the mechanisms and roles of mitochondrial dynamics by focussing on the nematode <em>Caenorhabditis elegans</em>. Whole live-animal studies in <em>C. elegans</em> have enabled a true organismal-level understanding of the impact that mitochondrial dynamics play in homeostasis over a lifetime.</p></div>\",\"PeriodicalId\":21735,\"journal\":{\"name\":\"Seminars in cell & developmental biology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2023-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1084952123002033/pdfft?md5=a0d52e7e69a0bc2a8b74d3f6825556d7&pid=1-s2.0-S1084952123002033-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Seminars in cell & developmental biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1084952123002033\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in cell & developmental biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1084952123002033","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
The mechanisms and roles of mitochondrial dynamics in C. elegans
If mitochondria are the powerhouses of the cell, then mitochondrial dynamics are the power grid that regulates how that energy output is directed and maintained in response to unique physiological demands. Fission and fusion dynamics are highly regulated processes that fine-tune the mitochondrial networks of cells to enable appropriate responses to intrinsic and extrinsic stimuli, thereby maintaining cellular and organismal homeostasis. These dynamics shape many aspects of an organism’s healthspan including development, longevity, stress resistance, immunity, and response to disease. In this review, we discuss the latest findings regarding the mechanisms and roles of mitochondrial dynamics by focussing on the nematode Caenorhabditis elegans. Whole live-animal studies in C. elegans have enabled a true organismal-level understanding of the impact that mitochondrial dynamics play in homeostasis over a lifetime.
期刊介绍：
Seminars in Cell and Developmental Biology is a review journal dedicated to keeping scientists informed of developments in the field of molecular cell and developmental biology, on a topic by topic basis. Each issue is thematic in approach, devoted to an important topic of interest to cell and developmental biologists, focusing on the latest advances and their specific implications.
The aim of each issue is to provide a coordinated, readable, and lively review of a selected area, published rapidly to ensure currency.
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