Ty Viet Pham, Duc Viet Ho, Anh Tuan Le, Y Duy Ngo, Nhan Thanh Thi Dang, Thang Quoc Le, Bao Chi Nguyen
{"title":"葛叶精油的化学成分和生物活性。","authors":"Ty Viet Pham, Duc Viet Ho, Anh Tuan Le, Y Duy Ngo, Nhan Thanh Thi Dang, Thang Quoc Le, Bao Chi Nguyen","doi":"10.1080/14786419.2023.2275739","DOIUrl":null,"url":null,"abstract":"<p><p>This study focused on the chemical composition and biological activities of the essential oil derived from <i>Grewia bulot</i>, a plant species known for its medicinal properties. The analysis of <i>Grewia bulot</i> essential oil revealed the presence of 78 constituents. The major compounds were <i>α</i>-cadinol (13.5%), 1,8-cineole (12.7%), 1,10-di-<i>epi</i>-cubenol (9.8%), <i>epi</i>-<i>α</i>-cadinol (6.7%), (<i>E</i>,<i>E</i>)-<i>α</i>-farnesene (5.9%), (<i>E</i>)-citral (4.0%), selin-11-en-4-<i>α</i>-ol (4.0%), citronellol isobutanoate (3.9%), and geranic acid (3.7%). The essential oil exhibited promising antioxidant potential with an IC<sub>50</sub> value of 452.65 ± 28.40 µg/mL in DPPH model. This oil did not show NO production inhibitory effect in RAW 264.7 cells. In addition, the essential oil exhibited significant cytotoxicity against KB, Hep-G2, MCF-7, and SK-LU-1 cancer cell lines, with IC<sub>50</sub> values ranging from 44.04 ± 1.47 to 74.20 ± 3.71 μg/mL.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"4106-4112"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chemical composition and biological activities of essential oil from <i>Grewia bulot</i> leaves.\",\"authors\":\"Ty Viet Pham, Duc Viet Ho, Anh Tuan Le, Y Duy Ngo, Nhan Thanh Thi Dang, Thang Quoc Le, Bao Chi Nguyen\",\"doi\":\"10.1080/14786419.2023.2275739\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study focused on the chemical composition and biological activities of the essential oil derived from <i>Grewia bulot</i>, a plant species known for its medicinal properties. The analysis of <i>Grewia bulot</i> essential oil revealed the presence of 78 constituents. The major compounds were <i>α</i>-cadinol (13.5%), 1,8-cineole (12.7%), 1,10-di-<i>epi</i>-cubenol (9.8%), <i>epi</i>-<i>α</i>-cadinol (6.7%), (<i>E</i>,<i>E</i>)-<i>α</i>-farnesene (5.9%), (<i>E</i>)-citral (4.0%), selin-11-en-4-<i>α</i>-ol (4.0%), citronellol isobutanoate (3.9%), and geranic acid (3.7%). The essential oil exhibited promising antioxidant potential with an IC<sub>50</sub> value of 452.65 ± 28.40 µg/mL in DPPH model. This oil did not show NO production inhibitory effect in RAW 264.7 cells. In addition, the essential oil exhibited significant cytotoxicity against KB, Hep-G2, MCF-7, and SK-LU-1 cancer cell lines, with IC<sub>50</sub> values ranging from 44.04 ± 1.47 to 74.20 ± 3.71 μg/mL.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"4106-4112\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2023.2275739\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/11/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2023.2275739","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/1 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Chemical composition and biological activities of essential oil from Grewia bulot leaves.
This study focused on the chemical composition and biological activities of the essential oil derived from Grewia bulot, a plant species known for its medicinal properties. The analysis of Grewia bulot essential oil revealed the presence of 78 constituents. The major compounds were α-cadinol (13.5%), 1,8-cineole (12.7%), 1,10-di-epi-cubenol (9.8%), epi-α-cadinol (6.7%), (E,E)-α-farnesene (5.9%), (E)-citral (4.0%), selin-11-en-4-α-ol (4.0%), citronellol isobutanoate (3.9%), and geranic acid (3.7%). The essential oil exhibited promising antioxidant potential with an IC50 value of 452.65 ± 28.40 µg/mL in DPPH model. This oil did not show NO production inhibitory effect in RAW 264.7 cells. In addition, the essential oil exhibited significant cytotoxicity against KB, Hep-G2, MCF-7, and SK-LU-1 cancer cell lines, with IC50 values ranging from 44.04 ± 1.47 to 74.20 ± 3.71 μg/mL.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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