提高蛋白质和肽治疗学稳定性和靶向效率的生物偶联技术。

IF 1.9 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Tanuja Bisht, Anupriya Adhikari, Shivanand Patil, Shivang Dhoundiyal
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引用次数: 0

摘要

生物偶联技术已成为增强蛋白质和肽治疗的稳定性和靶向效率的强大工具。这篇综述对该领域采用的各种生物偶联策略进行了全面分析。引言强调了生物偶联技术在解决蛋白质和肽类药物的稳定性和靶向挑战方面的重要性。讨论了化学和酶生物偶联方法,以及共价连接的交联策略和位点特异性偶联方法。探讨了生物偶联在改善稳定性方面的作用,展示了成功增强稳定性的案例研究。此外,还介绍了用于配体附着和靶向的生物偶联技术,以及靶向蛋白质和肽治疗的实例。该综述还涵盖了延长循环和控制释放的生物偶联方法,重点是延长半衰期、减少清除和设计控制释放系统的策略。生物偶联物的分析表征技术,包括偶联效率、稳定性的评估,以及生物活性和靶向效率的评估,都得到了彻底的检查。讨论了生物偶联蛋白质和肽疗法的体内考虑因素和临床应用,包括药代动力学和药效学考虑因素,以及临床前和临床发展。最后,综述总结了未来的前景,强调了新的偶联方法和先进的靶向策略的潜力,以进一步提高蛋白质和肽治疗的稳定性和靶向效率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bioconjugation Techniques for Enhancing Stability and Targeting Efficiency of Protein and Peptide Therapeutics.

Bioconjugation techniques have emerged as powerful tools for enhancing the stability and targeting efficiency of protein and peptide therapeutics. This review provides a comprehensive analysis of the various bioconjugation strategies employed in the field. The introduction highlights the significance of bioconjugation techniques in addressing stability and targeting challenges associated with protein and peptide-based drugs. Chemical and enzymatic bioconjugation methods are discussed, along with crosslinking strategies for covalent attachment and site-specific conjugation approaches. The role of bioconjugation in improving stability profiles is explored, showcasing case studies that demonstrate successful stability enhancement. Furthermore, bioconjugation techniques for ligand attachment and targeting are presented, accompanied by examples of targeted protein and peptide therapeutics. The review also covers bioconjugation approaches for prolonging circulation and controlled release, focusing on strategies to extend half-life, reduce clearance, and design-controlled release systems. Analytical characterization techniques for bioconjugates, including the evaluation of conjugation efficiency, stability, and assessment of biological activity and targeting efficiency, are thoroughly examined. In vivo considerations and clinical applications of bioconjugated protein and peptide therapeutics, including pharmacokinetic and pharmacodynamic considerations, as well as preclinical and clinical developments, are discussed. Finally, the review concludes with an overview of future perspectives, emphasizing the potential for novel conjugation methods and advanced targeting strategies to further enhance the stability and targeting efficiency of protein and peptide therapeutics.

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来源期刊
Current protein & peptide science
Current protein & peptide science 生物-生化与分子生物学
CiteScore
5.20
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.
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