在人肺癌癌症异种移植物模型中,SARS-CoV-2感染诱导硫运载蛋白-2的表达和分泌并调节铁。

IF 2.9 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
BMB Reports Pub Date : 2023-12-01
Sangkyu Park, Dongbum Kim, Jinsoo Kim, Hyung-Joo Kwon, Younghee Lee
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引用次数: 0

摘要

严重急性呼吸系统综合征冠状病毒2型感染会导致包括贫血在内的各种临床症状。脂蛋白-2具有多种生物学功能,包括通过铁螯合防御细菌感染,它是肾损伤的生物标志物。在人类蛋白质阵列中,我们观察到在Calu-3人类肺癌癌症细胞系中,由于亲代SARS-CoV-2感染,脂杯蛋白-2表达增加。脂质运载蛋白-2的分泌也因父母感染严重急性呼吸系统综合征冠状病毒2而升高,严重急性呼吸系冠状病毒2的阿尔法、贝塔和德尔塔变异株也类似地诱导了这种现象。在Calu-3植入的小鼠异种移植物模型中,亲代严重急性呼吸系统综合征冠状病毒2型和德尔塔变异株诱导脂质运载蛋白2的表达和分泌。此外,由于感染,Calu-3肿瘤组织中的铁浓度增加,血清中的铁含量降低。总之,严重急性呼吸系统综合征冠状病毒2型感染诱导脂质运载蛋白2的产生和分泌,可能导致血清中铁浓度下降。由于血液中铁离子的浓度与贫血有关,这种现象可能会导致新冠肺炎患者出现贫血。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SARS-CoV-2 infection induces expression and secretion of lipocalin-2 and regulates iron in a human lung cancer xenograft model.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to various clinical symptoms including anemia. Lipocalin-2 has various biological functions, including defense against bacterial infections through iron sequestration, and it serves as a biomarker for kidney injury. In a human protein array, we observed increased lipocalin-2 expression due to parental SARS-CoV-2 infection in the Calu-3 human lung cancer cell line. The secretion of lipocalin-2 was also elevated in response to parental SARS-CoV-2 infection, and the SARS-CoV-2 Alpha, Beta, and Delta variants similarly induced this phenomenon. In a Calu-3 implanted mouse xenograft model, parental SARSCoV- 2 and Delta variant induced lipocalin-2 expression and secretion. Additionally, the iron concentration increased in the Calu-3 tumor tissues and decreased in the serum due to infection. In conclusion, SARS-CoV-2 infection induces the production and secretion of lipocalin-2, potentially resulting in a decrease in iron concentration in serum. Because the concentration of iron ions in the blood is associated with anemia, this phenomenon could contribute to developing anemia in COVID-19 patients. [BMB Reports 2023; 56(12): 669-674].

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来源期刊
BMB Reports
BMB Reports 生物-生化与分子生物学
CiteScore
5.10
自引率
7.90%
发文量
141
审稿时长
1 months
期刊介绍: The BMB Reports (BMB Rep, established in 1968) is published at the end of every month by Korean Society for Biochemistry and Molecular Biology. Copyright is reserved by the Society. The journal publishes short articles and mini reviews. We expect that the BMB Reports will deliver the new scientific findings and knowledge to our readers in fast and timely manner.
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