T细胞淋巴细胞的衰老时钟：端粒、端粒酶和衰老。

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2024-04-01 Epub Date: 2023-11-02 DOI:10.1007/s10522-023-10075-6

Alain Chebly, Charbel Khalil, Alexandra Kuzyk, Marie Beylot-Barry, Edith Chevret

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引用次数: 0

摘要

衰老是指随着时间的推移，维持生命和繁殖所需的生理能力下降。人类免疫细胞，包括T细胞淋巴细胞，经历了与衰老相关的剧烈变化，包括与端粒和端粒酶相关的变化。研究表明，端粒和端粒酶在T细胞分化、衰老和疾病中发挥着至关重要的作用，包括在几种T细胞恶性肿瘤中证明的短端粒和端粒酶激活之间的联系。在此，我们对T细胞端粒和端粒酶在健康和年龄相关疾病中的文献进行了全面的综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

T-cell lymphocytes' aging clock: telomeres, telomerase and aging.

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T-cell lymphocytes' aging clock: telomeres, telomerase and aging.

Aging is the decline of physiological capabilities required for life maintenance and reproduction over time. The human immune cells, including T-cells lymphocytes, undergo dramatic aging-related changes, including those related to telomeres and telomerase. It was demonstrated that telomeres and telomerase play crucial roles in T-cell differentiation, aging, and diseases, including a well-documented link between short telomeres and telomerase activation demonstrated in several T-cells malignancies. Herein, we provide a comprehensive review of the literature regarding T-cells' telomeres and telomerase in health and age related-diseases.

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.