口腔HPV检测在口咽癌症诊断和监测中的现状和前景。评论。

IF 0.7 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Biomedical Papers-Olomouc Pub Date : 2023-12-01 Epub Date: 2023-10-20 DOI:10.5507/bp.2023.040
Zuzana Horakova, Ivo Starek, Richard Salzman
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引用次数: 0

摘要

口咽癌症(OPC)中HPV16的状态是一个重要的预后因素。根据p16癌蛋白的免疫化学分析,需要进行侵入性活检。因此,正在寻求替代方法。确定口服HPV16状态似乎是一个有前景的替代方案。然而,它并不是常规使用的。这促使我们进行了系统的文献综述,使我们能够评估这种方法的诊断和预测能力。最终选定了34项相关研究。对于OPC中HPV状态的测定,口腔取样的平均灵敏度和特异性分别为74%和91%,p16肿瘤组织标志物是金标准。该方法在监测治疗反应和肿瘤的生物活性方面似乎是有价值的,能够在其临床和/或放射学表现之前足够长的时间内早期检测到持续性或复发性癌症。在来源不明的转移病例中,它也有助于识别原发性肿瘤。最后但并非最不重要的是,筛查HPV口腔检测将有助于识别持续性HPV口腔感染的个体,这些个体患OPC的风险增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current status and future perspectives of oral HPV testing in the diagnosis and monitoring of oropharyngeal cancer. A review.

HPV16 status in oropharyngeal cancer (OPC) is an important prognostic factor. Its determination, based on immunistochemical analysis of p16 oncoprotein requires an invasive biopsy. Thus, alternative methods are being sought. Determining oral HPV16 status appears to be a promising alternative. However, it is not used routinely. This prompted us to perform a systematic literature review enabling us to evaluate the diagnostic and predictive ability of this approach. Thirty-four relevant studies were finally selected. For determination of HPV status in OPC, the calculated average sensitivity and specificity for oral sampling was 74% and 91%, respectively, with p16 tumour tissue marker being the gold standard. The method appears to be valuable in monitoring treatment response as well as the biological activity of the tumour, enabling early detection of persistent or relapsing carcinoma sufficiently long before its clinical and/or radiological manifestation. It can also contribute to identification of the primary tumour in cases of metastases of unknown origin. Last but not least, the screening HPV oral testing would help to identify individuals with persistent HPV oral infection who are at increased risk of development of OPC.

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来源期刊
Biomedical Papers-Olomouc
Biomedical Papers-Olomouc MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
2.30
自引率
0.00%
发文量
74
审稿时长
6-12 weeks
期刊介绍: Biomedical Papers is a journal of Palacký University Olomouc, Faculty of Medicine and Dentistry, Olomouc, Czech Republic. It includes reviews and original articles reporting on basic and clinical research in medicine. Biomedical Papers is published as one volume per year in four issues.
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