磷酸托卡替尼致狗顶泌腺-肛门囊腺癌的掌跖红感觉障碍综合征：一例报告。

IF 1.5 3区农林科学 Q2 VETERINARY SCIENCES

Journal of Veterinary Science Pub Date : 2023-11-01 Epub Date: 2023-10-04 DOI:10.4142/jvs.23163

Eunjoo Kim, Sung-Soo Kim, Min-Ok Ryu

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引用次数: 0

摘要

一只患有3期顶泌腺腺癌的11岁绝育雄性迷你贵宾犬在手术后开始接受磷酸托卡替尼化疗。从toceranib的第10天开始，狗的脚垫出现红斑和高度角化。这只狗抱怨疼痛、无法行走、抑郁和食欲不振。停药后症状消失，恢复用药后症状再次出现。根据VCOG-CTCAE和Naranjo量表，3级掌跖红感觉异常被确定为托卡替尼的不良事件。尽管在兽医学中非常罕见，但临床医生应该考虑到，托卡替尼给药后可能会出现掌跖红感觉异常。

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Palmar-plantar erythrodysesthesia syndrome resulting from toceranib phosphate in a dog with apocrine gland anal sac adenocarcinoma: a case report.

An 11-year-old neutered male Miniature Poodle with a stage 3 apocrine gland adenocarcinoma was started on chemotherapy with toceranib phosphate after surgery. Beginning on day 10 of toceranib, the dog's foot pads became erythematous and hyperkeratinized. The dog complained of pain, inability to walk, depression, and loss of appetite. The symptoms resolved when toceranib was discontinued and reappeared when toceranib was resumed. Grade 3 palmar-plantar erythrodysesthesia was identified as an adverse event of toceranib based on the VCOG-CTCAE and Naranjo scale. Although very rare in veterinary medicine, clinicians should consider that palmar-plantar erythrodysesthesia can occur after toceranib administration.

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来源期刊

Journal of Veterinary Science 农林科学-兽医学

CiteScore

3.10

自引率

5.60%

发文量

审稿时长

1.3 months

期刊介绍： The Journal of Veterinary Science (J Vet Sci) is devoted to the advancement and dissemination of scientific knowledge concerning veterinary sciences and related academic disciplines. It is an international journal indexed in the Thomson Scientific Web of Science, SCI-EXPANDED, Sci Search, BIOSIS Previews, Biological Abstracts, Focus on: Veterinary Science & Medicine, Zoological Record, PubMed /MEDLINE, Index Medicus, Pubmed Central, CAB Abstracts / Index Veterinarius, EBSCO, AGRIS and AGRICOLA. This journal published in English by the Korean Society of Veterinary Science (KSVS) being distributed worldwide.