西地那非治疗早产儿肺动脉高压1例临床分析

IF 0.3 Q4 PEDIATRICS

Journal of Pediatric and Neonatal Individualized Medicine Pub Date : 2015-02-09 DOI:10.7363/040108

G. A. Alyamovskaya, E. S. Keshishian, E. G. Verchenko, V. Bereznitskaya

{"title":"西地那非治疗早产儿肺动脉高压1例临床分析","authors":"G. A. Alyamovskaya, E. S. Keshishian, E. G. Verchenko, V. Bereznitskaya","doi":"10.7363/040108","DOIUrl":null,"url":null,"abstract":"We report the use of oral sildenafil in a 7-month-old preterm newborn with severe bronchopulmonary dysplasia and pulmonary arterial hypertension refractory to captopril and inhaled budesonide, and need of consistent oxygenation. Sildenafil was prepared as a powder for oral administration. Oral sildenafil treatment was continued for 11 months. Oxygen supplement was suspended after 4 months and captopril administration was finished after 7 months of sildenafil treatment. There were no adverse effects during the treatment period. The respiratory failure decreased significantly and pulmonary arterial pressure became normal after 7 months of sildenafil treatment.","PeriodicalId":51914,"journal":{"name":"Journal of Pediatric and Neonatal Individualized Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.3000,"publicationDate":"2015-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"The clinical case of sildenafil administration in a very premature infant with pulmonary hypertension\",\"authors\":\"G. A. Alyamovskaya, E. S. Keshishian, E. G. Verchenko, V. Bereznitskaya\",\"doi\":\"10.7363/040108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We report the use of oral sildenafil in a 7-month-old preterm newborn with severe bronchopulmonary dysplasia and pulmonary arterial hypertension refractory to captopril and inhaled budesonide, and need of consistent oxygenation. Sildenafil was prepared as a powder for oral administration. Oral sildenafil treatment was continued for 11 months. Oxygen supplement was suspended after 4 months and captopril administration was finished after 7 months of sildenafil treatment. There were no adverse effects during the treatment period. The respiratory failure decreased significantly and pulmonary arterial pressure became normal after 7 months of sildenafil treatment.\",\"PeriodicalId\":51914,\"journal\":{\"name\":\"Journal of Pediatric and Neonatal Individualized Medicine\",\"volume\":\"4 1\",\"pages\":\"\"},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2015-02-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pediatric and Neonatal Individualized Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7363/040108\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatric and Neonatal Individualized Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7363/040108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 1

摘要

我们报告了一名7个月大的早产儿使用口服西地那非治疗卡托普利和吸入布地奈德难治的严重支气管肺发育不良和肺动脉高压，需要持续氧合。将西地那非制成粉末状口服给药。口服西地那非治疗持续11个月。4个月后停止补氧，西地那非治疗7个月后停用卡托普利。治疗期间无不良反应发生。西地那非治疗7个月后呼吸衰竭明显减轻，肺动脉压恢复正常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The clinical case of sildenafil administration in a very premature infant with pulmonary hypertension

We report the use of oral sildenafil in a 7-month-old preterm newborn with severe bronchopulmonary dysplasia and pulmonary arterial hypertension refractory to captopril and inhaled budesonide, and need of consistent oxygenation. Sildenafil was prepared as a powder for oral administration. Oral sildenafil treatment was continued for 11 months. Oxygen supplement was suspended after 4 months and captopril administration was finished after 7 months of sildenafil treatment. There were no adverse effects during the treatment period. The respiratory failure decreased significantly and pulmonary arterial pressure became normal after 7 months of sildenafil treatment.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Pediatric and Neonatal Individualized Medicine PEDIATRICS-

CiteScore

1.00

自引率

25.00%

发文量

审稿时长

12 weeks

期刊介绍： The Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) is a peer-reviewed interdisciplinary journal which provides a forum on new perspectives in pediatric and neonatal medicine. The aim is to discuss and to bring readers up to date on the latest in research and clinical pediatrics and neonatology. Special emphasis is on developmental origin of health and disease or perinatal programming and on the so-called ‘-omic’ sciences. Systems medicine blazes a revolutionary trail from reductionist to holistic medicine, from descriptive medicine to predictive medicine, from an epidemiological perspective to a personalized approach. The journal will be relevance to clinicians and researchers concerned with personalized care for the newborn and child. Also medical humanities will be considered in a tailored way. Article submission (original research, review papers, invited editorials and clinical cases) will be considered in the following fields: fetal medicine, perinatology, neonatology, pediatrics, developmental programming, psychology and medical humanities.