Epitheilioid Trophoblastic Tumor of the Lung: A Case Report

Epithelioid trophoblastic tumor is a rare type of gestational trophoblastic disease that is distinct from placental site trophoblastic tumor and chorio carcinoma, and epithelioid trophoblastic tumor has features resembling a carcinoma. W e report here on an epithelioid trophoblastic tumor that w as discovered as a solitary pulm onary nodule in the lung of a 50-year-old woman . The patient had suffered from a hydatidiform mole 20 years previously. Wedge resection of the lung was done and this showed a 1.9x1.5 cm sized, relatively well defined mass composed of mononuclear tumor cells admixed wi th hyaline-like m aterial and necrosis. The tumor cells w ere positive for EMA, C am5. 2, α-inhibin, PLAP and hCG. After consulting the gynecologic department, a 7.5×6.5 cm sized mass was discovered in the uterine fundus. H ysterectomy w as then done. The tumor cells w ere same to those of the lung mass. The lung mass is considered to be metastasis from the epithelioid trophoblastic tumor of the uterus. She has been an uneventful clinical course for three years. (J Lung Cancer 2009;8(2):114 �� 117)