巴西人群il - 4基因rs2243250多态性与出血性中风的统计学关联

Q4 Medicine
Ângelo M. Rolim, Felipe Borges, A. Barros, Jonathan D. Lima, Fabiana B. A. Silva, Hélia Carla de Souza, D. Freire, L. Ferreira, Izabel Cristina R. Silva
{"title":"巴西人群il - 4基因rs2243250多态性与出血性中风的统计学关联","authors":"Ângelo M. Rolim, Felipe Borges, A. Barros, Jonathan D. Lima, Fabiana B. A. Silva, Hélia Carla de Souza, D. Freire, L. Ferreira, Izabel Cristina R. Silva","doi":"10.5935/1676-2444.20200031","DOIUrl":null,"url":null,"abstract":"Interleukin-4 (IL-4) has great significance in inflammatory processes in cases of stroke, since it is able to polarize microglia to the anti-inflammatory phenotype called M2. This study analyzed if the variation between TT genotype and the other genotypes (CT and CC), in -589 (rs2243250) polymorphism of IL4 gene, has association with the prognosis of hemorrhagic stroke (HS) and with clinical aspects which are risk factors for cerebrovascular diseases. The result of this study shows that there is no statistical association of the IL4 polymorphism with either prognosis or clinical aspects in HS patients.","PeriodicalId":35397,"journal":{"name":"Jornal Brasileiro de Patologia e Medicina Laboratorial","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Statistical association of rs2243250 polymorphism of IL4 gene and hemorrhagic stroke in Brazilian population\",\"authors\":\"Ângelo M. Rolim, Felipe Borges, A. Barros, Jonathan D. Lima, Fabiana B. A. Silva, Hélia Carla de Souza, D. Freire, L. Ferreira, Izabel Cristina R. Silva\",\"doi\":\"10.5935/1676-2444.20200031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Interleukin-4 (IL-4) has great significance in inflammatory processes in cases of stroke, since it is able to polarize microglia to the anti-inflammatory phenotype called M2. This study analyzed if the variation between TT genotype and the other genotypes (CT and CC), in -589 (rs2243250) polymorphism of IL4 gene, has association with the prognosis of hemorrhagic stroke (HS) and with clinical aspects which are risk factors for cerebrovascular diseases. The result of this study shows that there is no statistical association of the IL4 polymorphism with either prognosis or clinical aspects in HS patients.\",\"PeriodicalId\":35397,\"journal\":{\"name\":\"Jornal Brasileiro de Patologia e Medicina Laboratorial\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Jornal Brasileiro de Patologia e Medicina Laboratorial\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5935/1676-2444.20200031\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Jornal Brasileiro de Patologia e Medicina Laboratorial","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5935/1676-2444.20200031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

白细胞介素-4 (IL-4)在中风病例的炎症过程中具有重要意义,因为它能够使小胶质细胞极化为抗炎表型M2。本研究分析il - 4基因-589 (rs2243250)多态性中TT基因型与其他基因型(CT和CC)的差异是否与出血性卒中(HS)的预后及作为脑血管疾病危险因素的临床方面相关。本研究结果显示,在HS患者中,il - 4多态性与预后或临床方面均无统计学相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Statistical association of rs2243250 polymorphism of IL4 gene and hemorrhagic stroke in Brazilian population
Interleukin-4 (IL-4) has great significance in inflammatory processes in cases of stroke, since it is able to polarize microglia to the anti-inflammatory phenotype called M2. This study analyzed if the variation between TT genotype and the other genotypes (CT and CC), in -589 (rs2243250) polymorphism of IL4 gene, has association with the prognosis of hemorrhagic stroke (HS) and with clinical aspects which are risk factors for cerebrovascular diseases. The result of this study shows that there is no statistical association of the IL4 polymorphism with either prognosis or clinical aspects in HS patients.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Jornal Brasileiro de Patologia e Medicina Laboratorial
Jornal Brasileiro de Patologia e Medicina Laboratorial Health Professions-Medical Laboratory Technology
CiteScore
1.30
自引率
0.00%
发文量
0
审稿时长
20 weeks
期刊介绍: The Jornal Brasileiro de Patologia e Medicina Laboratorial (Brazilian Journal of Pathology and Laboratory Medicine), a continuation of Jornal Brasileiro de Patologia (Brazilian Journal of Pathology), and published quarterly (March, June, September and December) is directed towards the publication of scientific articles that contribute to the development of the area of Laboratory Medicine (Clinical Pathology, Pathology, Cytopathology). It accepts the following categories of articles: original articles, review articles, case reports, short communications, updating articles, letters to editors and reviews.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信