巴西人群il - 4基因rs2243250多态性与出血性中风的统计学关联

Q4 Medicine

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI:10.5935/1676-2444.20200031

Ângelo M. Rolim, Felipe Borges, A. Barros, Jonathan D. Lima, Fabiana B. A. Silva, Hélia Carla de Souza, D. Freire, L. Ferreira, Izabel Cristina R. Silva

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引用次数: 0

摘要

白细胞介素-4 (IL-4)在中风病例的炎症过程中具有重要意义，因为它能够使小胶质细胞极化为抗炎表型M2。本研究分析il - 4基因-589 (rs2243250)多态性中TT基因型与其他基因型(CT和CC)的差异是否与出血性卒中(HS)的预后及作为脑血管疾病危险因素的临床方面相关。本研究结果显示，在HS患者中，il - 4多态性与预后或临床方面均无统计学相关性。

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Statistical association of rs2243250 polymorphism of IL4 gene and hemorrhagic stroke in Brazilian population

Interleukin-4 (IL-4) has great significance in inflammatory processes in cases of stroke, since it is able to polarize microglia to the anti-inflammatory phenotype called M2. This study analyzed if the variation between TT genotype and the other genotypes (CT and CC), in -589 (rs2243250) polymorphism of IL4 gene, has association with the prognosis of hemorrhagic stroke (HS) and with clinical aspects which are risk factors for cerebrovascular diseases. The result of this study shows that there is no statistical association of the IL4 polymorphism with either prognosis or clinical aspects in HS patients.

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来源期刊

Jornal Brasileiro de Patologia e Medicina Laboratorial Health Professions-Medical Laboratory Technology

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Jornal Brasileiro de Patologia e Medicina Laboratorial (Brazilian Journal of Pathology and Laboratory Medicine), a continuation of Jornal Brasileiro de Patologia (Brazilian Journal of Pathology), and published quarterly (March, June, September and December) is directed towards the publication of scientific articles that contribute to the development of the area of Laboratory Medicine (Clinical Pathology, Pathology, Cytopathology). It accepts the following categories of articles: original articles, review articles, case reports, short communications, updating articles, letters to editors and reviews.