伴有和不伴有鼻息肉的慢性鼻窦炎患者鼻黏膜中筋膜蛋白的过表达

Q4 Medicine

Jornal Brasileiro de Patologia e Medicina Laboratorial Pub Date : 2020-01-01 DOI:10.5935/1676-2444.20200007

A. Tkachenko, G. Gubina-Vakulyck, A. Onishchenko, I. Kalashnyk, Ya. O. Butko, T. Gorbach

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引用次数: 0

摘要

目的:研究慢性鼻窦炎伴(CRSwNP)和不伴(CRSsNP)鼻息肉患者鼻组织中肌束蛋白的表达。方法:对11例CRSwNP患者和10例CRSsNP患者鼻组织中fastin的表达进行免疫组化评价，并与对照组进行比较。结果:在CRSwNP的息肉上皮细胞和CRSsNP的鼻组织中发现了fastin的强烈表达。在CRSsNP的固有层和鼻上皮细胞中均观察到其强表达。与CRSsNP相比，CRSwNP患者鼻黏膜中筋膜蛋白过表达更为明显。此外，息肉组织中的增殖上皮细胞免疫染色较弱，而成熟细胞表达更多的束蛋白。结论:CRSwNP和CRSsNP与筋膜蛋白过表达相关，使筋膜蛋白成为有希望的治疗干预靶点。

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Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps

Objective: The aim of our research is to assess fascin expression in nasal tissues of patients with chronic rhinosinusitis with (CRSwNP) and without (CRSsNP) nasal polyps. Methods: Fascin expression in nasal tissues of 11 CRSwNP patients and 10 CRSsNP patients was immunohistochemically evaluated and compared with control subjects. Results: Fascin was found to be strongly expressed in epithelial cells in polyps in CRSwNP and nasal tissue in CRSsNP. Its strong expression was observed both in lamina propria and nasal epithelial cells in CRSsNP. Fascin overexpression in nasal mucosa in CRSwNP was more pronounced compared with CRSsNP. In addition, proliferating epithelial cells in polyp tissue were weakly immunostained, whereas mature cells expressed much more fascin. Conclusion: CRSwNP and CRSsNP are associated with fascin overexpression, which makes fascin a promising target for therapeutic interventions.

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来源期刊

Jornal Brasileiro de Patologia e Medicina Laboratorial Health Professions-Medical Laboratory Technology

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： The Jornal Brasileiro de Patologia e Medicina Laboratorial (Brazilian Journal of Pathology and Laboratory Medicine), a continuation of Jornal Brasileiro de Patologia (Brazilian Journal of Pathology), and published quarterly (March, June, September and December) is directed towards the publication of scientific articles that contribute to the development of the area of Laboratory Medicine (Clinical Pathology, Pathology, Cytopathology). It accepts the following categories of articles: original articles, review articles, case reports, short communications, updating articles, letters to editors and reviews.