乙醛在酒精作用的代谢和机制中的重要性

IF 0.1 Q4 SUBSTANCE ABUSE

Alkoholizm i Narkomania-Alchoholism and Drug Addition Pub Date : 2018-01-01 DOI:10.5114/ain.2018.83913

W. Dyr, E. Wyszogrodzka

{"title":"乙醛在酒精作用的代谢和机制中的重要性","authors":"W. Dyr, E. Wyszogrodzka","doi":"10.5114/ain.2018.83913","DOIUrl":null,"url":null,"abstract":"Acetaldehyde is the first metabolite of ethanol and may be formed by alcohol dehydrogenase (ADH), cytochrome P450 2E1 (CYP2E1) and catalase. ADH is an essential pathway that oxidises alcohol in peripheral tissues (primarily in the liver). Acetaldehyde is oxidised to acetic acid by the aldehyde dehydrogenase (ALDH) enzyme. Acetaldehyde passes into the brain from the peripheral blood with difficulty, due to the blood-brain metabolic barrier, which is ALDH in the brain blood vessels. Acetaldehyde can be formed directly in the brain, mainly by catalase enzyme. Another important enzyme metabolising ethanol in central nervous system is CYP2E1. The gene mutation (ALDH2*2) causes an increase in the level of acetaldehyde in the blood Streszczenie","PeriodicalId":42147,"journal":{"name":"Alkoholizm i Narkomania-Alchoholism and Drug Addition","volume":"31 1","pages":"301-314"},"PeriodicalIF":0.1000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5114/ain.2018.83913","citationCount":"0","resultStr":"{\"title\":\"The importance of acetaldehydein the metabolism and mechanismof ethyl alcohol action\",\"authors\":\"W. Dyr, E. Wyszogrodzka\",\"doi\":\"10.5114/ain.2018.83913\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Acetaldehyde is the first metabolite of ethanol and may be formed by alcohol dehydrogenase (ADH), cytochrome P450 2E1 (CYP2E1) and catalase. ADH is an essential pathway that oxidises alcohol in peripheral tissues (primarily in the liver). Acetaldehyde is oxidised to acetic acid by the aldehyde dehydrogenase (ALDH) enzyme. Acetaldehyde passes into the brain from the peripheral blood with difficulty, due to the blood-brain metabolic barrier, which is ALDH in the brain blood vessels. Acetaldehyde can be formed directly in the brain, mainly by catalase enzyme. Another important enzyme metabolising ethanol in central nervous system is CYP2E1. The gene mutation (ALDH2*2) causes an increase in the level of acetaldehyde in the blood Streszczenie\",\"PeriodicalId\":42147,\"journal\":{\"name\":\"Alkoholizm i Narkomania-Alchoholism and Drug Addition\",\"volume\":\"31 1\",\"pages\":\"301-314\"},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.5114/ain.2018.83913\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alkoholizm i Narkomania-Alchoholism and Drug Addition\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/ain.2018.83913\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"SUBSTANCE ABUSE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alkoholizm i Narkomania-Alchoholism and Drug Addition","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/ain.2018.83913","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}

引用次数: 0

摘要

乙醛是乙醇的第一代谢产物，可由乙醇脱氢酶(ADH)、细胞色素P450 2E1 (CYP2E1)和过氧化氢酶形成。ADH是外周组织(主要是肝脏)氧化酒精的重要途径。乙醛被醛脱氢酶(ALDH)酶氧化成乙酸。由于血脑代谢障碍，乙醛很难从外周血进入大脑，这是脑血管中的ALDH。乙醛可以在大脑中直接形成，主要是通过过氧化氢酶。另一种在中枢神经系统中代谢乙醇的重要酶是CYP2E1。基因突变(ALDH2*2)导致血液中乙醛水平升高

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The importance of acetaldehydein the metabolism and mechanismof ethyl alcohol action

Acetaldehyde is the first metabolite of ethanol and may be formed by alcohol dehydrogenase (ADH), cytochrome P450 2E1 (CYP2E1) and catalase. ADH is an essential pathway that oxidises alcohol in peripheral tissues (primarily in the liver). Acetaldehyde is oxidised to acetic acid by the aldehyde dehydrogenase (ALDH) enzyme. Acetaldehyde passes into the brain from the peripheral blood with difficulty, due to the blood-brain metabolic barrier, which is ALDH in the brain blood vessels. Acetaldehyde can be formed directly in the brain, mainly by catalase enzyme. Another important enzyme metabolising ethanol in central nervous system is CYP2E1. The gene mutation (ALDH2*2) causes an increase in the level of acetaldehyde in the blood Streszczenie

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Alkoholizm i Narkomania-Alchoholism and Drug Addition SUBSTANCE ABUSE-

自引率

0.00%

发文量

审稿时长

13 weeks