由佐剂(硅胶乳房植入物和唇部填充物)诱导的自身免疫性炎症综合征

Božidar Pocevski, S. Pavlov-Dolijanovic
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引用次数: 0

摘要

自1962年以来,硅胶乳房植入物(SBI)一直用于乳房切除术后的重建,隆胸或美容目的,而生物聚合物填充物(FB)自20世纪90年代以来一直使用。今天,它们被认为是免疫系统的佐剂。SBI和FB的大多数并发症本质上是局部的,但一些患者会出现全身性症状,这些症状被定义为佐剂诱导的自身免疫性炎症综合征(ASIA)。目的:本研究的目的是证明硅胶乳房植入物和FB与免疫介导的炎症性风湿性疾病(IMIRD)发展的可能关联。材料与方法:本研究为回顾性研究,纳入15例女性免疫介导炎性风湿病患者,其中6例因美容原因植入硅胶乳房假体,9例唇部植入生物聚合物填充物。结果:从硅胶植入到出现首次症状的平均时间为6.10±5.3(6个月~ 24年)。记录了以下免疫介导的炎性风湿病:系统性硬化症(SSc) 3例,未分化关节炎3例,血清阳性类风湿性关节炎3例,系统性红斑狼疮1例,未分化SCTD 2例,混合性结缔组织病2例,不明原因全身性疾病1例。7名患者出现雷诺现象。2例发生自然流产。结论:早期报道硅胶乳房植入物和生物聚合物填充物是安全的,今天随着亚洲综合征的描述而改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Autoimmune inflammatory syndrome induced by adjuvants (silicone breast implants and lip fillers)
Introduction: Silicone breast implants (SBI) have been used since 1962 in the reconstruction of post-mastectomy cases, in augmentation of the breast, or for cosmetic purposes, while fillers with biopolymer (FB) have been used since the 1990s. Today, they are considered adjuvants of the immune system. Most complications of SBI and FB are local in nature, but some patients experience systemic symptoms, which are defined as adjuvant-induced autoimmune inflammatory syndrome (ASIA). Aim: The aim of this study is to demonstrate the possible association of silicone breast implants and FB with the development of immune-mediated inflammatory rheumatic diseases (IMIRD). Material and methods: The research represents retrospective study which involved 15 female patients with immune-mediated inflammatory rheumatic diseases, 6 of whom were patients with implanted silicone breast implants for cosmetic reasons, and 9 patients with placement of fillers with biopolymer on the lips. Results: The average time from silicone implantation to the onset of the first symptoms was 6.10 ± 5.3 (range 6 months to 24 years). The following immune-mediated inflammatory rheumatic diseases were recorded: 3 patients with systemic sclerosis (SSc), 3 patients with undifferentiated arthritis, 3 patients with seropositive rheumatoid arthritis, 1 patient with systemic lupus erythematosus, 2 patients with undifferentiated SCTD, 2 patients with mixed connective tissue disease, and one patient with unexplained systemic disease. Seven patients had the Raynaud phenomenon. Spontaneous abortions were reported in 2 patients. Conclusion: Earlier reports that silicone breast implants and biopolymer fillers are safe, today are changing with the description of ASIA syndrome.
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