病毒相关癌症中Hippo信号通路的解除管制

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
Emad Behboudi, M. Hashemzadeh, A. Ramezani, Ali Jari, Negar Ebrahimi, Somayeh Ghasemi, M. Makvandi, Tahereh Gholamzadeh, E. Faghihloo
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引用次数: 0

摘要

Hippo信号被认为是一种新发现的肿瘤抑制信号通路,可以调节包括再生、细胞死亡、分化和发育在内的细胞过程。作为Hippo通路的两个主要致癌因子,YAP (Yes-associated protein)和TAZ (PDZ-binding motif)的过度表达导致其失调,在多种癌症中起着至关重要的作用。由于预后和治疗靶点有限,进一步了解参与肿瘤发生的分子途径是研究中的有趣问题之一。在这里,我们证明了一些病毒,通过对Hippo信号通路的失调,可以参与病毒相关癌症的转化、转移和化疗耐药性,也有助于病毒感染的发病机制,如持久性。”
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Deregulation of the Hippo Signaling Pathway in Virus-Associated Cancer
"Hippo signaling has been recognized as a newly identified tumor suppressor signaling pathway that can regulate cellular processes including regeneration, cell death, differentiation, and development. Its dysregulation through overexpression of YAP (Yes-associated protein) and TAZ (PDZ-binding motif) as two main oncogenic factors of the Hippo pathway has a crucial role in several cancers. Because of the limited prognosis and therapeutic targets, further understanding of molecular pathways involved in tumorigenesis is one of the interesting issues in studies. Here, we demonstrated that some viruses, through dysregulation of the Hippo signaling pathway can be implicated in transformation, metastasis, and chemotherapeutic drug resistance in virus-related cancer and also help processes involved in the pathogenesis of viral infection such as persistence "
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来源期刊
Romanian Journal of Military Medicine
Romanian Journal of Military Medicine MEDICINE, GENERAL & INTERNAL-
自引率
33.30%
发文量
2
审稿时长
12 weeks
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