{"title":"外泌体微rna在结直肠癌中的临床应用","authors":"Cai X, Bao X, Xu C, Li T, Wang Q, Wang X, Li H","doi":"10.47829/jjgh.2022.8701","DOIUrl":null,"url":null,"abstract":"Exosomes are nanometer-sized membrane vesicles secreted by normal or cancer cells, which participate in intercellular communication by transporting RNAs and proteins. Recent studies have found that some differentially expressed microRNAs (miRNAs) in exosomes play key roles in the initiation and development of Colorectal Cancer (CRC) and are potential candidates for CRC detection. In this review, we describe the role of exosomal miRNAs in the development of CRC. We also briefly summarize the methods used for exosome extraction and enrichment. Finally, we examine the potential roles of exosomal miRNAs as biomarkers for the diagnosis of and prognostic assessment of CRC, as well as novel molecules for targeted therapy","PeriodicalId":73535,"journal":{"name":"Japanese journal of gastroenterology and hepatology","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Utility of Exosomal Micrornas for Colorectal Cancer\",\"authors\":\"Cai X, Bao X, Xu C, Li T, Wang Q, Wang X, Li H\",\"doi\":\"10.47829/jjgh.2022.8701\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Exosomes are nanometer-sized membrane vesicles secreted by normal or cancer cells, which participate in intercellular communication by transporting RNAs and proteins. Recent studies have found that some differentially expressed microRNAs (miRNAs) in exosomes play key roles in the initiation and development of Colorectal Cancer (CRC) and are potential candidates for CRC detection. In this review, we describe the role of exosomal miRNAs in the development of CRC. We also briefly summarize the methods used for exosome extraction and enrichment. Finally, we examine the potential roles of exosomal miRNAs as biomarkers for the diagnosis of and prognostic assessment of CRC, as well as novel molecules for targeted therapy\",\"PeriodicalId\":73535,\"journal\":{\"name\":\"Japanese journal of gastroenterology and hepatology\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Japanese journal of gastroenterology and hepatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47829/jjgh.2022.8701\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese journal of gastroenterology and hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47829/jjgh.2022.8701","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Clinical Utility of Exosomal Micrornas for Colorectal Cancer
Exosomes are nanometer-sized membrane vesicles secreted by normal or cancer cells, which participate in intercellular communication by transporting RNAs and proteins. Recent studies have found that some differentially expressed microRNAs (miRNAs) in exosomes play key roles in the initiation and development of Colorectal Cancer (CRC) and are potential candidates for CRC detection. In this review, we describe the role of exosomal miRNAs in the development of CRC. We also briefly summarize the methods used for exosome extraction and enrichment. Finally, we examine the potential roles of exosomal miRNAs as biomarkers for the diagnosis of and prognostic assessment of CRC, as well as novel molecules for targeted therapy
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