修饰碳糊电极电位法测定盐酸羟美唑啉

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-01-01 DOI:10.4152/pea.2021390505

Y. M. Issa, M. Khalil, S. I. Zayed, N. Mustafa

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引用次数: 0

摘要

以邻苯二甲酸二丁酯和邻苯二甲酸二辛酯为溶剂介质，以四苯基硼酸钠(NaTPB)或邻苯二甲酸铵为离子对配合物，构建了两种用于盐酸羟甲唑啉的碳糊电极。该电极在3.98x10 ~ 1x10 M的浓度范围内具有快速、稳定的响应，在浓度10年内的近似能量斜率分别为59.0、58.2 mV，检出限(LOD)分别为3.31x10和3.72x10 M。该电极已成功地应用于阿夫林滴鼻制剂中盐酸羟甲唑啉的测定。

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Potentiometric Determination of Oxymetazoline Hydrochloride Using Modified Carbon Paste Electrodes

Two carbon paste electrodes for oxymetazoline hydrochloride were constructed based on ion pair complexes of this drug, with sodium tetraphenylborate (NaTPB) or ammonium reineckate, using dibutyl phthalate and dioctyl phthalate as solvent mediators, respectively. The developed electrodes displayed a fast, stable response over the concentration range from 3.98x10 to 1x10 M oxymetazoline hydrochloride, with a near-nernstian slope of 59.0, 58.2 mV of concentration decade and a limit of detection (LOD) of 3.31x10 and 3.72x10 M, in the oxymetazoline-tetraphenylborate and oxymetazoline-reineckate cases, respectively. The developed electrodes have been successfully applied for oxymetazoline hydrochloride determination in the Afrin nasal drop pharmaceutical formulation.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.