APTES包被Fe3O4作为桑酮抗癌药物载体的合成与表征

生物材料与纳米技术(英文) Pub Date : 2015-09-16 DOI:10.4236/JBNB.2015.64025

B. Saif, Congli Wang, D. Chuan, S. Shuang

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引用次数: 39

摘要

桑里素(MR)是一种存在于水果和中草药中的抗癌药物。采用傅里叶红外(FTIR)、透射电镜(TEM)、x射线衍射(XRD)、动态光散射(DLS)和振动样品磁强计(VSM)等手段对Fe3O4磁性纳米粒子(MNPs-APTES)作为mr载体进行了表征。利用FTIR对吸附在磁铁矿表面的APTES (MNPs-APTES)进行了表征。TEM图像显示，MNPs-APTES的平均粒径约为26.7 nm。研究了MNPs-APTES的MR加载和释放行为，结果表明，高达60%的吸附药物在4小时内被释放。综上所述，MNPs-APTES纳米载体是基于该结果的，有望用于靶向药物递送。

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Synthesis and Characterization of Fe3O4 Coated on APTES as Carriers for Morin-Anticancer Drug

Morin (MR) is an anticancer drug present in fruits and Chinese herbs. Fe3O4 magnetic nanoparticles (MNPs) coated on 3-aminopropyl triethoxysilane (APTES) were synthesized (MNPs-APTES) as carriers for MR. The characterization of drug delivery system was confirmed by Fourier Transform Infrared (FTIR), Transmission Electron Microscope (TEM), X-Ray Diffraction (XRD), dynamic light scattering (DLS), and vibrating sample magnetometer (VSM). The adsorbed APTES on the magnetite surface (MNPs-APTES) was examined by FTIR. The TEM image showed that the average particle size is obtained to be about 26.7 nm for MNPs-APTES. The MR loading and release behavior of MNPs-APTES were studied and the results showed that up to 60% of the adsorbed drug was released within 4 h. In summary, the MNPs-APTES nanocarriers are based on the results, promising for targeted morin drug delivery.

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来源期刊

生物材料与纳米技术(英文)

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