先前肌肉注射疫苗失败的肝移植患者皮下注射高剂量乙型肝炎疫苗:一个简短的病例报告

S. Dhillon, K. Sampath, C. Moore, A. Dosanjh, D. Thiel
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引用次数: 1

摘要

乙型肝炎病毒(HBV)慢性感染是世界范围内发病率和死亡率的重要原因。虽然传统的肌肉注射(IM) HBV疫苗接种是健康个体稳健和持续血清转化的一种极好的方法,但其在慢性肝病中的疗效并不理想,并且在肝移植后状态下存在缺乏数据。重要的是,在这些免疫功能低下的人群中,HBV并发症甚至更为严重。皮内(ID)疫苗接种已经显示出初步的希望,作为一种成功的替代方法,可以在对标准疫苗接种方案难治性的患者中实现HBV血清转化。本文报告一例61岁女性因慢性HBV感染接受肝移植,在接种标准剂量和双剂量IM疫苗失败后,接种ID疫苗后HBsAg血清转化为HSsAb滴度高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-Dose Intra-Dermal Hepatitis B Vaccine in a Liver Transplant Patient Who Failed Prior Intramuscular Vaccination: A Brief Case Report
Hepatitis B virus (HBV) chronic infection represents a significant cause of morbidity and mortality worldwide. While traditional intramuscular (IM) HBV vaccination is an excellent method for robust and sustained seroconversion in healthy individuals, its efficacy in chronic liver disease is sub-optimal and scant data exists in the post-liver transplant state. Importantly, HBV complications are even more severe in these same immunocompromised populations. Intra-dermal (ID) vaccination has shown initial promise as a successful alternative to achieving HBV seroconversion in patients refractory to standard vaccination protocols. Herein is a case report of a 61 year-old female who underwent liver transplantation for chronic HBV infection and achieved HBsAg seroconversion with a robust HSsAb titer with ID vaccination after having failed both standard and double dose IM vaccination.
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