小儿长春新碱全神经病量表检测急性淋巴细胞白血病患儿长春新碱诱导的周围神经病变

IF 0.4 Q3 MEDICINE, GENERAL & INTERNAL
P. Gunawan, Kartika Hardiyani, I. Ugrasena
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引用次数: 0

摘要

目的:分析小儿长春新碱全神经病变量表(TNS-PV)评分作为长春新碱诱导的周围神经病变(VIPN)的诊断工具。方法:本观察性分析研究在Soetomo医生医院儿科血液肿瘤科门诊进行。纳入标准是4-18岁的急性淋巴细胞白血病(ALL)儿童,接受化疗,长春新碱累积剂量bbb12mg /m2,无肌肉无力并签署知情同意。采用TNS-PV仪评估VIPN,以神经传导研究(NCS)为金标准。结果:共有54名儿童入组,其中2名拒绝签署知情同意书。约60%为男童,76.9%年龄<10岁,94%为ALL-L1。TNS-PV曲线下面积(AUC)为0.638 (95% CI 0.531 ~ 0.834),截断值为3.5。灵敏度为87.9%;特异性42.1%,阳性预测值72.5%;阴性预测值(NPV) 66.6%, OR(优势比)5273。结论:TNS-PV评分不能代替NCS作为金标准,但TNS-PV可作为诊断VIPN的替代工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Total Neuropathy Scale Pediatric Vincristine to detect vincristine induced peripheral neuropathy in children with Acute Lymphoblastic Leukemia
Objective: To analyze the Total Neuropathy Scale Pediatric Vincristine (TNS-PV) score as a vincristine induced peripheral neuropathy (VIPN) diagnostic tool. Methodology: This observational analytic study was conducted in Outpatient Pediatric Hematology Oncology Dr. Soetomo Hospital. The inclusion criteria were Acute Lymphoblastic Leukemia (ALL) children aged 4-18 years that had undergone chemotherapy treatment, received a cumulative dose of vincristine >12 mg/m2, had no muscle weakness and signed informed consent. The TNS-PV instrument were used to assess VIPN and nerve conduction studies (NCS) was used as the gold standard. Results: A total of 54 children were enrolled, two refused to sign the informed consent. About 60% were male children, 76.9% aged <10 years old, and 94% were ALL-L1. The TNS-PV had an area under the curve (AUC) of 0.638 (95% CI 0.531-0.834) with cut off value of 3.5. It had a sensitivity 87.9%; specificity 42.1%, positive predictive value 72.5%; negative predictive value (NPV) 66.6% and OR (Odds ratio) 5,273. Conclusion: TNS-PV score cannot replace NCS as the gold standard, but TNS-PV can be an alternative tool for diagnosing VIPN.
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来源期刊
Rawal Medical Journal
Rawal Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
0.00%
发文量
6
期刊介绍: RMJ is a general Medicine publication and accepts oorigial articles, editorials, case reports and commentaries. It aims to dessiminate medical knowldge to professional community.
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