粘附分子和细胞角蛋白突变与毛囊疾病的关系

L. Silva, R. Hsieh, R. Romiti, A. Anzai, B. Rocha, S. Lourenço, N. Valente, J. Fernandes
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引用次数: 0

摘要

粘附分子和细胞角蛋白对毛囊的发育和维持至关重要。这些分子似乎负责毛囊胚芽的下降和信号与间充质细胞的正常发育毛囊。在成年期,它们的功能变化与许多导致毛干紊乱和瘢痕性和非瘢痕性脱发的病理有关。本文综述了主要的粘附分子:钙粘蛋白、整合蛋白和细胞角蛋白及其与毛囊病理的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship of mutation in adhesion molecules and cytokeratins with hair follicle diseases
Adhesion molecules and cytokeratins are essential for the development of hair follicles and their maintenance. These molecules seem to be responsible for the follicular germ downgrowth and signaling with mesenchymal cells for the correct development of hair follicles. In adulthood, changes in their functions are related to numerous pathologies that lead to hair shaft disorders and cicatricial and non-cicatricial alopecia. This work reviews the main adhesion molecules: cadherins, integrins and cytokeratins and their relationship with hair follicle pathologies.
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