L. Silva, R. Hsieh, R. Romiti, A. Anzai, B. Rocha, S. Lourenço, N. Valente, J. Fernandes
{"title":"粘附分子和细胞角蛋白突变与毛囊疾病的关系","authors":"L. Silva, R. Hsieh, R. Romiti, A. Anzai, B. Rocha, S. Lourenço, N. Valente, J. Fernandes","doi":"10.5455/im.54631","DOIUrl":null,"url":null,"abstract":"Adhesion molecules and cytokeratins are essential for the development of hair follicles and their maintenance. These molecules seem to be responsible for the follicular germ downgrowth and signaling with mesenchymal cells for the correct development of hair follicles. In adulthood, changes in their functions are related to numerous pathologies that lead to hair shaft disorders and cicatricial and non-cicatricial alopecia. This work reviews the main adhesion molecules: cadherins, integrins and cytokeratins and their relationship with hair follicle pathologies.","PeriodicalId":93574,"journal":{"name":"International medicine (Antioch, Turkey)","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relationship of mutation in adhesion molecules and cytokeratins with hair follicle diseases\",\"authors\":\"L. Silva, R. Hsieh, R. Romiti, A. Anzai, B. Rocha, S. Lourenço, N. Valente, J. Fernandes\",\"doi\":\"10.5455/im.54631\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Adhesion molecules and cytokeratins are essential for the development of hair follicles and their maintenance. These molecules seem to be responsible for the follicular germ downgrowth and signaling with mesenchymal cells for the correct development of hair follicles. In adulthood, changes in their functions are related to numerous pathologies that lead to hair shaft disorders and cicatricial and non-cicatricial alopecia. This work reviews the main adhesion molecules: cadherins, integrins and cytokeratins and their relationship with hair follicle pathologies.\",\"PeriodicalId\":93574,\"journal\":{\"name\":\"International medicine (Antioch, Turkey)\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International medicine (Antioch, Turkey)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5455/im.54631\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International medicine (Antioch, Turkey)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5455/im.54631","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Relationship of mutation in adhesion molecules and cytokeratins with hair follicle diseases
Adhesion molecules and cytokeratins are essential for the development of hair follicles and their maintenance. These molecules seem to be responsible for the follicular germ downgrowth and signaling with mesenchymal cells for the correct development of hair follicles. In adulthood, changes in their functions are related to numerous pathologies that lead to hair shaft disorders and cicatricial and non-cicatricial alopecia. This work reviews the main adhesion molecules: cadherins, integrins and cytokeratins and their relationship with hair follicle pathologies.