Rawat Kavita, Azad Sheenam, Bahal Neelima, Bisht S Jitender
{"title":"疱疹性天疱疮中不寻常的直接免疫荧光（DIF）模式--一份病例报告。","authors":"Rawat Kavita, Azad Sheenam, Bahal Neelima, Bisht S Jitender","doi":"10.4103/IJPM.IJPM_879_20","DOIUrl":null,"url":null,"abstract":"<p><p>Pemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA deposits along basement zone. Indirect immunofluorescence (IIF) revealed antibodies to desmoglein1 (Dsg-1) positive. A final diagnosis of PH was given. The patient responded well to treatment with dapsone and steroids.</p>","PeriodicalId":13488,"journal":{"name":"Indian Journal of Pathology and Microbiology","volume":"1 1","pages":"852-854"},"PeriodicalIF":0.8000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unusual direct immunofluorescence (DIF) pattern in pemphigus herpetiformis- A case report.\",\"authors\":\"Rawat Kavita, Azad Sheenam, Bahal Neelima, Bisht S Jitender\",\"doi\":\"10.4103/IJPM.IJPM_879_20\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA deposits along basement zone. Indirect immunofluorescence (IIF) revealed antibodies to desmoglein1 (Dsg-1) positive. A final diagnosis of PH was given. The patient responded well to treatment with dapsone and steroids.</p>\",\"PeriodicalId\":13488,\"journal\":{\"name\":\"Indian Journal of Pathology and Microbiology\",\"volume\":\"1 1\",\"pages\":\"852-854\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Pathology and Microbiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/IJPM.IJPM_879_20\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Pathology and Microbiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/IJPM.IJPM_879_20","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
丘疹性荨麻疹（Pemphigus herpetiformis，PH）是一种自身免疫性上皮内大疱性皮肤病。一名 61 岁的女性患者因全身多处瘙痒性糜烂、溃疡和头皮弥漫性脱发而就诊。口腔和生殖器粘膜未受影响。组织病理学检查发现，角质层下分离，表皮上皮变薄，中性粒细胞海绵状增生，齿嵴延长。直接免疫荧光（DIF）显示，细胞间区的 IgG 沉积呈鱼网状，基底区有局灶性线状 IgA 沉积。间接免疫荧光（IIF）显示去甲斑鸠蛋白1（Dsg-1）抗体呈阳性。最终诊断为 PH。患者对达塞酮和类固醇治疗反应良好。
Unusual direct immunofluorescence (DIF) pattern in pemphigus herpetiformis- A case report.
Pemphigus herpetiformis (PH) is an autoimmune intraepithelial bullous skin disorder. A 61-year-old female presented with history of multiple pruritic erosions, ulcers all over body, and diffuse loss of hair over scalp. Oral and genital mucosas were uninvolved. Subcorneal separation with suprapapillary thinning of epidermis, neutrophilic spongiosis, and elongation of rete ridges were seen on histopathology. Direct immunofluorescence (DIF) revealed IgG deposits in intercellular zone in fish net like pattern and focal linear IgA deposits along basement zone. Indirect immunofluorescence (IIF) revealed antibodies to desmoglein1 (Dsg-1) positive. A final diagnosis of PH was given. The patient responded well to treatment with dapsone and steroids.
期刊介绍：
The journal will cover studies related to pathology including morbid anatomy, surgical pathology, clinical pathology, diagnostic cytopathology including gynecologic cytology and aspiration cytology, hematology including immuno-hematology and medical microbiology. The journal gives preference to clinically oriented studies over experimental and animal studies. The Journal would publish peer-reviewed original research papers, case reports, systematic reviews, meta-analysis, letters to the editor and brief communications. Review articles on current topics usually are invited by the editor.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
