赛斯林的第一次合成

有机化学国际期刊(英文) Pub Date : 2014-12-26 DOI:10.4236/IJOC.2014.45033

Viktor Ilkei, Kornél Faragó, Zsuzsanna Sánta, M. Dékány, L. Hazai, C. Szántay, G. Kalaus

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引用次数: 8

摘要

无梗五加碱是近年来从无梗五加果实中分离得到的一种生物碱。该分子包含两个五元杂环单元，由一个酰基氨基甲醇-醚型键连接在一起。本文首次以琥珀酰亚胺和糠醇为原料，以5-羟基吡咯烷酮-2- 1和5-羟甲基糠醛为原料，简单合成了赛斯林。偶联反应在均匀加热条件下进行。

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The First Synthesis of Sessiline

Sessiline is an alkaloid which is recently isolated from the fruits of Acanthopanax sessiliflorus. The molecule contains two five-membered heterocyclic units joined together by an acylaminocarbinol-ether type bond. Here, we describe the first, simple synthesis of sessiline from 5-hydroxypyrrolidin-2-one and 5-hydroxymethylfurfural, which are prepared from succinimide and furfuryl alcohol, respectively. The coupling reaction takes place on moderate heating under neat conditions.

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来源期刊

有机化学国际期刊(英文)

自引率

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发文量

297