茴香固定油的鉴定与药理评价

IF 0.6 4区 化学 Q4 CHEMISTRY, MULTIDISCIPLINARY
A. R. A Rauf, T. A. T Ahmad, H. A. H Ahmad, I. A. K. I A Khan, S. U. A. S. S U A Shah, A. A Ali, N. M. N Muhammad, Y. S. A. A. O. B. Y S Al Awthan O Bahattab, M. A. A. D. M A Al Duais, M. S. M. M S Mubarak
{"title":"茴香固定油的鉴定与药理评价","authors":"A. R. A Rauf, T. A. T Ahmad, H. A. H Ahmad, I. A. K. I A Khan, S. U. A. S. S U A Shah, A. A Ali, N. M. N Muhammad, Y. S. A. A. O. B. Y S Al Awthan O Bahattab, M. A. A. D. M A Al Duais, M. S. M. M S Mubarak","doi":"10.52568/001196/jcsp/45.01.2023","DOIUrl":null,"url":null,"abstract":"Syzygium cumini L is an evergreen medicinal plant belonging to the family Myrtaceae, and is one of the important species of the genus Syzygium. S. cumini is traditionally used to treat various infections such as sore throat, bronchitis, dysentery, and other painful conditions. The aim of the current study was to evaluate fixed oil extracted from S. cumini for various in vitro and in vivo biological activities and identification of its fatty acids constituents. GC-MS analysis of the fixed oil revealed that the major constituents are palmitic acid methyl ester (56.45%) and stearic acid methyl ester (29.54%). Fixed oil isolated from S. cumini exhibited significant effect against Staphylococcus aureus, Shigella flexenari, and Bacillus subtilis with zone of inhibition of 28.09, 27.34, and 22.76 mm, respectively. In addition, the oil exhibited antifungal effect against Aspergillus flavus, Candida glabrata, Microsporum canis, and Fusarium solani with zone of inhibition of 80.77, 75.08, 70.98, and 65.56 mm, respectively. The oil also exerted analgesic potential at the dose of 10, 20, 40, and 60 mg/Kg with 35.44, 50.45, 65.98, and 80.34 % activity in acetic acid-induced writhing model. A mild muscle relaxant effect was noted in animal models. Taken all together, the fixed oil from S. cumini exhibits significant antimicrobial, antifungal and analgesic effects, which justifies the use of this plant in folk medicine.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Identification and Pharmacological Evaluation of Syzygium cumini Derived Fixed Oils\",\"authors\":\"A. R. A Rauf, T. A. T Ahmad, H. A. H Ahmad, I. A. K. I A Khan, S. U. A. S. S U A Shah, A. A Ali, N. M. N Muhammad, Y. S. A. A. O. B. Y S Al Awthan O Bahattab, M. A. A. D. M A Al Duais, M. S. M. M S Mubarak\",\"doi\":\"10.52568/001196/jcsp/45.01.2023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Syzygium cumini L is an evergreen medicinal plant belonging to the family Myrtaceae, and is one of the important species of the genus Syzygium. S. cumini is traditionally used to treat various infections such as sore throat, bronchitis, dysentery, and other painful conditions. The aim of the current study was to evaluate fixed oil extracted from S. cumini for various in vitro and in vivo biological activities and identification of its fatty acids constituents. GC-MS analysis of the fixed oil revealed that the major constituents are palmitic acid methyl ester (56.45%) and stearic acid methyl ester (29.54%). Fixed oil isolated from S. cumini exhibited significant effect against Staphylococcus aureus, Shigella flexenari, and Bacillus subtilis with zone of inhibition of 28.09, 27.34, and 22.76 mm, respectively. In addition, the oil exhibited antifungal effect against Aspergillus flavus, Candida glabrata, Microsporum canis, and Fusarium solani with zone of inhibition of 80.77, 75.08, 70.98, and 65.56 mm, respectively. The oil also exerted analgesic potential at the dose of 10, 20, 40, and 60 mg/Kg with 35.44, 50.45, 65.98, and 80.34 % activity in acetic acid-induced writhing model. A mild muscle relaxant effect was noted in animal models. Taken all together, the fixed oil from S. cumini exhibits significant antimicrobial, antifungal and analgesic effects, which justifies the use of this plant in folk medicine.\",\"PeriodicalId\":17253,\"journal\":{\"name\":\"Journal of the chemical society of pakistan\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the chemical society of pakistan\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.52568/001196/jcsp/45.01.2023\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the chemical society of pakistan","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.52568/001196/jcsp/45.01.2023","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

金合欢是桃金娘科常绿药用植物,是金合欢属重要种之一。传统上,猪链球菌用于治疗各种感染,如喉咙痛、支气管炎、痢疾和其他疼痛状况。本研究的目的是评价鱼尾草固定油的各种体外和体内生物活性,并鉴定其脂肪酸成分。GC-MS分析表明,该固定油的主要成分为棕榈酸甲酯(56.45%)和硬脂酸甲酯(29.54%)。对金黄色葡萄球菌、flexenari志贺氏菌和枯草芽孢杆菌的抑制区分别为28.09、27.34和22.76 mm。对黄曲霉、光念珠菌、canmicrosporum和solani Fusarium的抑制区分别为80.77、75.08、70.98和65.56 mm。在10、20、40和60 mg/Kg剂量下,其镇痛活性分别为35.44%、50.45%、65.98%和80.34%。在动物模型中观察到轻微的肌肉松弛作用。综上所述,该植物的固定油具有显著的抗菌、抗真菌和镇痛作用,证明了该植物在民间医学中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification and Pharmacological Evaluation of Syzygium cumini Derived Fixed Oils
Syzygium cumini L is an evergreen medicinal plant belonging to the family Myrtaceae, and is one of the important species of the genus Syzygium. S. cumini is traditionally used to treat various infections such as sore throat, bronchitis, dysentery, and other painful conditions. The aim of the current study was to evaluate fixed oil extracted from S. cumini for various in vitro and in vivo biological activities and identification of its fatty acids constituents. GC-MS analysis of the fixed oil revealed that the major constituents are palmitic acid methyl ester (56.45%) and stearic acid methyl ester (29.54%). Fixed oil isolated from S. cumini exhibited significant effect against Staphylococcus aureus, Shigella flexenari, and Bacillus subtilis with zone of inhibition of 28.09, 27.34, and 22.76 mm, respectively. In addition, the oil exhibited antifungal effect against Aspergillus flavus, Candida glabrata, Microsporum canis, and Fusarium solani with zone of inhibition of 80.77, 75.08, 70.98, and 65.56 mm, respectively. The oil also exerted analgesic potential at the dose of 10, 20, 40, and 60 mg/Kg with 35.44, 50.45, 65.98, and 80.34 % activity in acetic acid-induced writhing model. A mild muscle relaxant effect was noted in animal models. Taken all together, the fixed oil from S. cumini exhibits significant antimicrobial, antifungal and analgesic effects, which justifies the use of this plant in folk medicine.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
1.30
自引率
14.30%
发文量
41
审稿时长
3.4 months
期刊介绍: This journal covers different research areas in the field of Chemistry. These include; Analytical Chemistry, Applied Chemistry, Biochemistry, Environmental Chemistry, Industrial Chemistry, Inorganic Chemistry, Organic Chemistry and Physical Chemistry. The journal publishes full length articles and Reviews from researchers in academia in addition to featuring comments. Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信