百合花胆碱酯酶抑制萜类化合物

IF 0.6 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Journal of the chemical society of pakistan Pub Date : 2023-01-01 DOI:10.52568/001194/jcsp/45.01.2023

Muhammad Afzal Muhammad Afzal, Ejaz Ahmed Ejaz Ahmed, Ahsan Sharif Ahsan Sharif

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引用次数: 0

摘要

合欢是植物化合物的有效来源。在植物化学研究中，从药用植物合欢的氯仿可溶性组分中分离到一种新的三萜合欢酸A。通过物理、化学和光谱分析(FT-IR, 1Dandamp;二维核磁共振，质谱)。这种生物活性化合物对阿尔茨海默病(AD)引起的乙酰胆碱酯酶(AChE)和丁基胆碱酯酶(BChE)具有抑制潜力。albizinoacid A对胆碱酯酶的IC50分别为25.3和177;乙酰胆碱酯酶为0.02，乙酰胆碱酯酶为19.0，#177;0.05, AChE和8.5，#177;0.01,BChE)。酶活性分析表明，藻酸A具有很大的药理潜力。

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Cholinesterase Inhibiting Terpenoid from Albizia kalkora

Albizia kalkora is potent source of phytocompounds. In recent phytochemical investigation one new triterpenoid Albizinoic acid A was isolated from the chloroform soluble fraction of medicinal plant Albizia kalkora. The structure was elucidated by physical, chemical, and spectroscopic analysis (FT-IR, 1Dandamp; 2D-NMR, Mass spectrometry). This bioactive compound exhibited inhibitory potential against Alzheimer’s disease (AD) causing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). IC50 of Albizinoic acid A against cholinesterase were found 25.3and#177; 0.02, AChE and 19.0and#177;0.03, BChE while galanthamine as a positive control (0.5 and#177; 0.05, AChE and 8.5and#177;0.01, BChE). This enzymes assay indicated that Albizinoic acid A has great potential of pharmacological characteristics.

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来源期刊

Journal of the chemical society of pakistan 化学-化学综合

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

3.4 months

期刊介绍： This journal covers different research areas in the field of Chemistry. These include; Analytical Chemistry, Applied Chemistry, Biochemistry, Environmental Chemistry, Industrial Chemistry, Inorganic Chemistry, Organic Chemistry and Physical Chemistry. The journal publishes full length articles and Reviews from researchers in academia in addition to featuring comments. Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry.