百合花胆碱酯酶抑制萜类化合物

IF 0.6 4区 化学 Q4 CHEMISTRY, MULTIDISCIPLINARY
Muhammad Afzal Muhammad Afzal, Ejaz Ahmed Ejaz Ahmed, Ahsan Sharif Ahsan Sharif
{"title":"百合花胆碱酯酶抑制萜类化合物","authors":"Muhammad Afzal Muhammad Afzal, Ejaz Ahmed Ejaz Ahmed, Ahsan Sharif Ahsan Sharif","doi":"10.52568/001194/jcsp/45.01.2023","DOIUrl":null,"url":null,"abstract":"Albizia kalkora is potent source of phytocompounds. In recent phytochemical investigation one new triterpenoid Albizinoic acid A was isolated from the chloroform soluble fraction of medicinal plant Albizia kalkora. The structure was elucidated by physical, chemical, and spectroscopic analysis (FT-IR, 1Dandamp; 2D-NMR, Mass spectrometry). This bioactive compound exhibited inhibitory potential against Alzheimer’s disease (AD) causing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). IC50 of Albizinoic acid A against cholinesterase were found 25.3and#177; 0.02, AChE and 19.0and#177;0.03, BChE while galanthamine as a positive control (0.5 and#177; 0.05, AChE and 8.5and#177;0.01, BChE). This enzymes assay indicated that Albizinoic acid A has great potential of pharmacological characteristics.","PeriodicalId":17253,"journal":{"name":"Journal of the chemical society of pakistan","volume":null,"pages":null},"PeriodicalIF":0.6000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cholinesterase Inhibiting Terpenoid from Albizia kalkora\",\"authors\":\"Muhammad Afzal Muhammad Afzal, Ejaz Ahmed Ejaz Ahmed, Ahsan Sharif Ahsan Sharif\",\"doi\":\"10.52568/001194/jcsp/45.01.2023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Albizia kalkora is potent source of phytocompounds. In recent phytochemical investigation one new triterpenoid Albizinoic acid A was isolated from the chloroform soluble fraction of medicinal plant Albizia kalkora. The structure was elucidated by physical, chemical, and spectroscopic analysis (FT-IR, 1Dandamp; 2D-NMR, Mass spectrometry). This bioactive compound exhibited inhibitory potential against Alzheimer’s disease (AD) causing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). IC50 of Albizinoic acid A against cholinesterase were found 25.3and#177; 0.02, AChE and 19.0and#177;0.03, BChE while galanthamine as a positive control (0.5 and#177; 0.05, AChE and 8.5and#177;0.01, BChE). This enzymes assay indicated that Albizinoic acid A has great potential of pharmacological characteristics.\",\"PeriodicalId\":17253,\"journal\":{\"name\":\"Journal of the chemical society of pakistan\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the chemical society of pakistan\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.52568/001194/jcsp/45.01.2023\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the chemical society of pakistan","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.52568/001194/jcsp/45.01.2023","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

合欢是植物化合物的有效来源。在植物化学研究中,从药用植物合欢的氯仿可溶性组分中分离到一种新的三萜合欢酸A。通过物理、化学和光谱分析(FT-IR, 1Dandamp;二维核磁共振,质谱)。这种生物活性化合物对阿尔茨海默病(AD)引起的乙酰胆碱酯酶(AChE)和丁基胆碱酯酶(BChE)具有抑制潜力。albizinoacid A对胆碱酯酶的IC50分别为25.3和177;乙酰胆碱酯酶为0.02,乙酰胆碱酯酶为19.0,#177;0.05, AChE和8.5,#177;0.01,BChE)。酶活性分析表明,藻酸A具有很大的药理潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cholinesterase Inhibiting Terpenoid from Albizia kalkora
Albizia kalkora is potent source of phytocompounds. In recent phytochemical investigation one new triterpenoid Albizinoic acid A was isolated from the chloroform soluble fraction of medicinal plant Albizia kalkora. The structure was elucidated by physical, chemical, and spectroscopic analysis (FT-IR, 1Dandamp; 2D-NMR, Mass spectrometry). This bioactive compound exhibited inhibitory potential against Alzheimer’s disease (AD) causing enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). IC50 of Albizinoic acid A against cholinesterase were found 25.3and#177; 0.02, AChE and 19.0and#177;0.03, BChE while galanthamine as a positive control (0.5 and#177; 0.05, AChE and 8.5and#177;0.01, BChE). This enzymes assay indicated that Albizinoic acid A has great potential of pharmacological characteristics.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
1.30
自引率
14.30%
发文量
41
审稿时长
3.4 months
期刊介绍: This journal covers different research areas in the field of Chemistry. These include; Analytical Chemistry, Applied Chemistry, Biochemistry, Environmental Chemistry, Industrial Chemistry, Inorganic Chemistry, Organic Chemistry and Physical Chemistry. The journal publishes full length articles and Reviews from researchers in academia in addition to featuring comments. Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信