{"title":"对SARS-CoV-2的免疫反应。重点关注重症COVID-19发病机制","authors":"R. Pawliczak","doi":"10.5114/pja.2020.99243","DOIUrl":null,"url":null,"abstract":"SARS-CoV-2 pandemics increased research in the interaction of coronaviruses with human immune response Moreover, a detailed analysis of SARS-CoV-2 immune response might be helpful in vaccine development and delivering some other therapeutic approaches Several papers described SARS and MERS antiviral response Unfortunately, not all data derived from SARS and MERS studies could be directly applied to the SARS-CoV-2 immune response, its clinical course and severe COVID-19 pathology In this paper we are trying to summarize basic aspects of COVID-19 immunopathology focusing on immune response, pathogenesis of severe disease and the differences between SARS-CoV-2 and its predecessors Moreover, we are trying to outline possible therapeutic approaches including but not limited to vaccines All reviewed data have to be treated with caution Next months and years will generate more results helping us to deal with SARS-CoV-2, which will confirm or disprove current information and the understanding of COVID-19","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"The immune response to SARS-CoV-2. Focus on severe COVID-19 pathogenesis\",\"authors\":\"R. Pawliczak\",\"doi\":\"10.5114/pja.2020.99243\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"SARS-CoV-2 pandemics increased research in the interaction of coronaviruses with human immune response Moreover, a detailed analysis of SARS-CoV-2 immune response might be helpful in vaccine development and delivering some other therapeutic approaches Several papers described SARS and MERS antiviral response Unfortunately, not all data derived from SARS and MERS studies could be directly applied to the SARS-CoV-2 immune response, its clinical course and severe COVID-19 pathology In this paper we are trying to summarize basic aspects of COVID-19 immunopathology focusing on immune response, pathogenesis of severe disease and the differences between SARS-CoV-2 and its predecessors Moreover, we are trying to outline possible therapeutic approaches including but not limited to vaccines All reviewed data have to be treated with caution Next months and years will generate more results helping us to deal with SARS-CoV-2, which will confirm or disprove current information and the understanding of COVID-19\",\"PeriodicalId\":7469,\"journal\":{\"name\":\"Alergologia Polska - Polish Journal of Allergology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alergologia Polska - Polish Journal of Allergology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/pja.2020.99243\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alergologia Polska - Polish Journal of Allergology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/pja.2020.99243","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ALLERGY","Score":null,"Total":0}
The immune response to SARS-CoV-2. Focus on severe COVID-19 pathogenesis
SARS-CoV-2 pandemics increased research in the interaction of coronaviruses with human immune response Moreover, a detailed analysis of SARS-CoV-2 immune response might be helpful in vaccine development and delivering some other therapeutic approaches Several papers described SARS and MERS antiviral response Unfortunately, not all data derived from SARS and MERS studies could be directly applied to the SARS-CoV-2 immune response, its clinical course and severe COVID-19 pathology In this paper we are trying to summarize basic aspects of COVID-19 immunopathology focusing on immune response, pathogenesis of severe disease and the differences between SARS-CoV-2 and its predecessors Moreover, we are trying to outline possible therapeutic approaches including but not limited to vaccines All reviewed data have to be treated with caution Next months and years will generate more results helping us to deal with SARS-CoV-2, which will confirm or disprove current information and the understanding of COVID-19
期刊介绍:
Alergologia Polska - Polish Journal of Allergology is aimed mainly at allergologists, but also medical doctors working in related fields, such as otolaryngology, pulmonology, and dermatology. The main goal of the journal is to ensure rapid publication of important research papers and interesting case studies from the following areas: allergology, diagnostics, therapy of allergic diseases, in particular in the area of immunotherapy, rhinitis, asthma. The Editorial Board accepts for publication original papers, case studies and letters to the Editor. We also publish review articles (both commissioned and those agreed upon with the Editor-in-Chief), articles dealing with standards of medical practice, as well as special issues. The journal is published quarterly. We guarantee short review times (up to two weeks) and immediate publication on-line upon Editor acceptance.