Berat Ebik, Nazım Ekin, Ferhat Bacaksiz, Ali Uzel, Mustafa Zanyar Akkuzu, Feyzullah Ucmak, Muhsin Kaya, Vedat Goral
{"title":"微小结肠炎患者中乳糜泻的发病率是多少?为什么这两种疾病有关联?","authors":"Berat Ebik, Nazım Ekin, Ferhat Bacaksiz, Ali Uzel, Mustafa Zanyar Akkuzu, Feyzullah Ucmak, Muhsin Kaya, Vedat Goral","doi":"10.5114/pg.2023.126855","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Although there are studies in the literature showing that celiac disease (CD) is more common in patients with microscopic colitis (MC), there are publications to the contrary. The pathophysiologies of both diseases are different from each other.</p><p><strong>Aim: </strong>To investigate the frequency of CD in MC patients, the different features of these 2 diseases, and the relationship between them.</p><p><strong>Material and methods: </strong>In our prospective and cross-sectional analytical study, the presence of CD was investigated in 90 patients diagnosed with MC by colonoscopy and biopsy due to chronic diarrhoea between September 2011 and December 2021.</p><p><strong>Results: </strong>We detected MC in 102 (9.3%) of 1096 patients investigated for chronic diarrhoea. We detected CD in 1 (1.1%) of 90 patients with MC who participated in the study. Only 10% of the patients were positive for AGA IgA, 3.3% for EMA IgA, and 2.2% for Anti-TG2 IgA. There was no difference in autoantibody titre in treatment-responsive and treatment-resistant MC patients. HLA DQ2 was positive in 32.2% (<i>n</i> = 29) of the MC patients, and HLA DQ8 was found in 5.5% (<i>n</i> = 5). Intraepithelial lymphocyte increase was remarkable in the duodenal biopsies of MC patients who did not respond to treatment (40% vs. 11.4%; <i>p</i> = 0.007).</p><p><strong>Conclusions: </strong>We did not reach the conclusion that CD is more common in MC patients. An increase in IEL may also occur in the small intestine in patients with MC who do not respond to treatment.</p>","PeriodicalId":20719,"journal":{"name":"Przegla̜d Gastroenterologiczny","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985763/pdf/","citationCount":"0","resultStr":"{\"title\":\"What is the incidence of celiac disease in patients with microscopic colitis? Why are these two diseases related?\",\"authors\":\"Berat Ebik, Nazım Ekin, Ferhat Bacaksiz, Ali Uzel, Mustafa Zanyar Akkuzu, Feyzullah Ucmak, Muhsin Kaya, Vedat Goral\",\"doi\":\"10.5114/pg.2023.126855\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Although there are studies in the literature showing that celiac disease (CD) is more common in patients with microscopic colitis (MC), there are publications to the contrary. The pathophysiologies of both diseases are different from each other.</p><p><strong>Aim: </strong>To investigate the frequency of CD in MC patients, the different features of these 2 diseases, and the relationship between them.</p><p><strong>Material and methods: </strong>In our prospective and cross-sectional analytical study, the presence of CD was investigated in 90 patients diagnosed with MC by colonoscopy and biopsy due to chronic diarrhoea between September 2011 and December 2021.</p><p><strong>Results: </strong>We detected MC in 102 (9.3%) of 1096 patients investigated for chronic diarrhoea. We detected CD in 1 (1.1%) of 90 patients with MC who participated in the study. Only 10% of the patients were positive for AGA IgA, 3.3% for EMA IgA, and 2.2% for Anti-TG2 IgA. There was no difference in autoantibody titre in treatment-responsive and treatment-resistant MC patients. HLA DQ2 was positive in 32.2% (<i>n</i> = 29) of the MC patients, and HLA DQ8 was found in 5.5% (<i>n</i> = 5). Intraepithelial lymphocyte increase was remarkable in the duodenal biopsies of MC patients who did not respond to treatment (40% vs. 11.4%; <i>p</i> = 0.007).</p><p><strong>Conclusions: </strong>We did not reach the conclusion that CD is more common in MC patients. An increase in IEL may also occur in the small intestine in patients with MC who do not respond to treatment.</p>\",\"PeriodicalId\":20719,\"journal\":{\"name\":\"Przegla̜d Gastroenterologiczny\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985763/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Przegla̜d Gastroenterologiczny\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5114/pg.2023.126855\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/4/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Przegla̜d Gastroenterologiczny","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5114/pg.2023.126855","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/4/24 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
导言:尽管有文献研究显示乳糜泻(CD)在显微镜下结肠炎(MC)患者中更为常见,但也有文献对此持相反观点。目的:研究 CD 在 MC 患者中的发病率、这两种疾病的不同特征以及它们之间的关系:在我们的前瞻性横断面分析研究中,对2011年9月至2021年12月期间因慢性腹泻而通过结肠镜检查和活检确诊为MC的90名患者进行了调查:在 1096 名接受检查的慢性腹泻患者中,我们发现 102 人(9.3%)患有 MC。在参与研究的 90 名 MC 患者中,我们在 1 人(1.1%)中发现了 CD。只有 10% 的患者 AGA IgA 呈阳性,3.3% 的患者 EMA IgA 呈阳性,2.2% 的患者抗 TG2 IgA 呈阳性。对治疗有反应的 MC 患者和对治疗有反应的 MC 患者的自身抗体滴度没有差异。32.2% 的 MC 患者(n = 29)HLA DQ2 呈阳性,5.5% 的患者(n = 5)HLA DQ8 呈阳性。对治疗无反应的 MC 患者的十二指肠活检组织中上皮内淋巴细胞显著增加(40% 对 11.4%;P = 0.007):结论:我们没有得出 MC 患者更常见 CD 的结论。结论:我们并未得出CD在MC患者中更为常见的结论。在治疗无效的MC患者中,小肠中的IEL也可能增加。
What is the incidence of celiac disease in patients with microscopic colitis? Why are these two diseases related?
Introduction: Although there are studies in the literature showing that celiac disease (CD) is more common in patients with microscopic colitis (MC), there are publications to the contrary. The pathophysiologies of both diseases are different from each other.
Aim: To investigate the frequency of CD in MC patients, the different features of these 2 diseases, and the relationship between them.
Material and methods: In our prospective and cross-sectional analytical study, the presence of CD was investigated in 90 patients diagnosed with MC by colonoscopy and biopsy due to chronic diarrhoea between September 2011 and December 2021.
Results: We detected MC in 102 (9.3%) of 1096 patients investigated for chronic diarrhoea. We detected CD in 1 (1.1%) of 90 patients with MC who participated in the study. Only 10% of the patients were positive for AGA IgA, 3.3% for EMA IgA, and 2.2% for Anti-TG2 IgA. There was no difference in autoantibody titre in treatment-responsive and treatment-resistant MC patients. HLA DQ2 was positive in 32.2% (n = 29) of the MC patients, and HLA DQ8 was found in 5.5% (n = 5). Intraepithelial lymphocyte increase was remarkable in the duodenal biopsies of MC patients who did not respond to treatment (40% vs. 11.4%; p = 0.007).
Conclusions: We did not reach the conclusion that CD is more common in MC patients. An increase in IEL may also occur in the small intestine in patients with MC who do not respond to treatment.
期刊介绍:
Gastroenterology Review is a journal published each 2 months, aimed at gastroenterologists and general practitioners. Published under the patronage of Consultant in Gastroenterology and Polish Pancreatic Club.