Solitary Non Small Cell Lung Cancer Metastasis to the Hypophysis: A CaseReport

Introduction: There are few cases in the literature pituitary metastasis. In this situation, 20% of metastases are from lung cancers. In most cases are asymptomatic, being diagnosed by imaging tests, but poor patient prognosis. Case Presentation: A 65-years-old, Brazilian-Caucasian, male patient was admitted with clinical weight loss, fever and appetite loss. Imaging studies show lung mass and mass lesion and sellar and suprasellar. His blood hormone profile was compatiple with secondary pan-hypopituitarism due to destruction of hypophysis. A biopsy confirmed a metastatic lesion from lung adenocarcinoma to the pituitary. The patient was submitted to stereotatic radiotherapy and started chemotherapy with cisplatin 50 mg/m2 D1 and D8, and etoposide D1 to D5 each 28 days for two cycles concomitant to 3D-conformational irradiation of the lung nodule and mediastinal lymph nodes, followed by two additional cycles of cisplatin and etoposide as consolidation. Conclusion: The treatment decision when dealing with isolated non-small cell lung cancer metastasis to the hypophysis, always need a multidisciplinary discussion, since it can range from radiotherapy and chemotherapy to surgery, and its choice is based upon clinical presentation, prognosis and disease extension as well as patient preference, weighing risks and benefits of each available strategy.