{"title":"重组人促红细胞生成素大鼠红细胞的血液学、代谢和流变学特性研究ii。流变特性","authors":"N. Maeda","doi":"10.3925/jjtc1958.35.633","DOIUrl":null,"url":null,"abstract":"HEMATOLOGICAL, METABOLIC AND RHEOLOGICAL CHARACTERISTICS OF ERYTHROCYTES IN RECOMBINANT HUMAN ERYTHROPOIETIN-ADMINISTERED RAT II. Rheological Properties Nobuji Maeda Department of Physiology, School of Medicine, Ehime University Rheological properties of erythrocytes induced by intravenous administration of recombinant human erythropoietin (rhEPO; 180 or 1800 IU/kg daily) to 6 weeks-old rats for 1 or 2 weeks were examined. (1) Increase of blood viscosity was entirely dependent upon the hematocrit. (2) No change of erythrocyte deformability was detected with a high shear rheoscope, in spite of the appearance of large and light (presumably, young) erythrocytes. (3) Velocity of rouleau formation in autologous plasma decreased, probably due to high density of negative charge on the surface of young erythrocytes. In addition, the composition of plasma proteins was not affected by rhEPO-administration. (4) Upon the long-term administration, these rheological findings were not essentially altered.","PeriodicalId":86521,"journal":{"name":"Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"HEMATOLOGICAL, METABOLIC AND RHEOLOGICAL CHARACTERISTICS OF ERYTHROCYTES IN RECOMBINANT HUMAN ERYTHROPOIETIN-ADMINISTERED RAT II. Rheological Properties\",\"authors\":\"N. Maeda\",\"doi\":\"10.3925/jjtc1958.35.633\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"HEMATOLOGICAL, METABOLIC AND RHEOLOGICAL CHARACTERISTICS OF ERYTHROCYTES IN RECOMBINANT HUMAN ERYTHROPOIETIN-ADMINISTERED RAT II. Rheological Properties Nobuji Maeda Department of Physiology, School of Medicine, Ehime University Rheological properties of erythrocytes induced by intravenous administration of recombinant human erythropoietin (rhEPO; 180 or 1800 IU/kg daily) to 6 weeks-old rats for 1 or 2 weeks were examined. (1) Increase of blood viscosity was entirely dependent upon the hematocrit. (2) No change of erythrocyte deformability was detected with a high shear rheoscope, in spite of the appearance of large and light (presumably, young) erythrocytes. (3) Velocity of rouleau formation in autologous plasma decreased, probably due to high density of negative charge on the surface of young erythrocytes. In addition, the composition of plasma proteins was not affected by rhEPO-administration. (4) Upon the long-term administration, these rheological findings were not essentially altered.\",\"PeriodicalId\":86521,\"journal\":{\"name\":\"Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3925/jjtc1958.35.633\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nihon Yuketsu Gakkai zasshi = Journal of the Japan Society of Blood Transfusion","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3925/jjtc1958.35.633","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
HEMATOLOGICAL, METABOLIC AND RHEOLOGICAL CHARACTERISTICS OF ERYTHROCYTES IN RECOMBINANT HUMAN ERYTHROPOIETIN-ADMINISTERED RAT II. Rheological Properties
HEMATOLOGICAL, METABOLIC AND RHEOLOGICAL CHARACTERISTICS OF ERYTHROCYTES IN RECOMBINANT HUMAN ERYTHROPOIETIN-ADMINISTERED RAT II. Rheological Properties Nobuji Maeda Department of Physiology, School of Medicine, Ehime University Rheological properties of erythrocytes induced by intravenous administration of recombinant human erythropoietin (rhEPO; 180 or 1800 IU/kg daily) to 6 weeks-old rats for 1 or 2 weeks were examined. (1) Increase of blood viscosity was entirely dependent upon the hematocrit. (2) No change of erythrocyte deformability was detected with a high shear rheoscope, in spite of the appearance of large and light (presumably, young) erythrocytes. (3) Velocity of rouleau formation in autologous plasma decreased, probably due to high density of negative charge on the surface of young erythrocytes. In addition, the composition of plasma proteins was not affected by rhEPO-administration. (4) Upon the long-term administration, these rheological findings were not essentially altered.
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