Chill Burn after Cryotherapy in a Thrombocytopenic Recipient: TheAdverse Effect of Thrombocytopenia on Dermal Wounding

Oral cryotherapy is an evidence-proven standard care for cancer patients. The efficacy of oral cryotherapy during chemotherapy is established especially for the treatment using melphalan. However, the patients’ neutrophil and platelet are usually decreased when undergoing cytotoxic chemotherapy, and the influence of which has not been fully evaluated clinically. We experienced the case complicated with chill burn like skin wound by direct damage of cryotherapy and discussed the function of neutrophils and platelets in the process of wound healing.