关于神经类固醇和情绪,我们需要知道些什么?

IF 0.7 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
F. di Michele, E. Romeo
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引用次数: 0

摘要

神经类固醇是一种重要的内源性化合物,可以调节许多与大脑有关的功能。神经类固醇影响大脑中的兴奋性(谷氨酸)和抑制性(γ-氨基丁酸,GABA)系统,从而调节广泛的情绪和行为。它们的合成在压力下增加,帮助生物体恢复体内平衡。因此,神经类固醇浓度的改变在压力和与压力相关的疾病的病理生理学中起作用,例如情绪(因此对悲伤和愤怒起作用)和焦虑(恐惧)障碍。本文综述了异孕酮、孕酮、孕烯醇酮、硫酸孕烯醇酮和脱氢表雄酮等神经活性化合物在调节情绪中的作用,并概述了它们目前在不同病理中的药理作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What do we need to know about neurosteroids and emotions?
Neurosteroids are essential endogenous compounds which modulate numerous brain-related functions. Neurosteroids affect both the excitatory (glutamate) and the inhibitory (γ-aminobutyric acid, GABA) systems in the brain allowing for the modulation of a wide array of emotions and behaviors. Their synthesis is increased in response to stress, helping the organism to return to homeostasis. Alterations of neurosteroid concentrations therefore have a role in the pathophysiology of stress and stress-related conditions, such as mood (therefore acting on sadness and anger) and anxiety (fear) disorders. Here, we summarize the action of some neuroactive compounds, such as allopregnanolone, pregnanolone, pregnenolone, pregnenolone sulfate and dehydroepiandrosterone, in regulating emotions and outline their current pharmacological use in different pathologies.
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来源期刊
AIMS Molecular Science
AIMS Molecular Science BIOCHEMISTRY & MOLECULAR BIOLOGY-
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4
审稿时长
5 weeks
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