家蚕本地寄主植物天然生物活性代谢物抗氧化和抗菌猪病的比较分析

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Manasee Choudhury, Shamima Parbin, S. Pegu, S. Banik, P. J. Das
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引用次数: 0

摘要

本研究探讨了寄主植物Antheraea assamensis (muga silkworm)中存在的天然生物活性代谢物、抗氧化和抗菌活性。山茱萸(som),山茱萸(sualu),山茱萸(dighloti)和枸杞(mejankari)。以2,2-二苯基-1-苦酰肼为自由基,对这些植物叶片的甲醇提取物进行了植物化学分析和自由基清除活性的筛选。植物化学分析显示,上述植物中存在黄酮类化合物、酚类化合物、类胡萝卜素、皂苷、香豆素、萜类、单宁、心脏糖苷和黄质蛋白。2,2-二苯基-1-苦味酰肼清除活性的结果表明,山苍子多花具有较强的抗氧化能力。此外,还研究了植物提取物对猪体内革兰氏阳性金黄色葡萄球菌和猪链球菌以及革兰氏阴性多杀性巴氏杆菌和大肠杆菌的抑菌效果。所有植物提取物均具有不同效价的抗菌活性。对革兰氏阳性菌和革兰氏阴性菌抑菌效果最好的是枸杞子提取物,其次是水杨花提取物、山茱萸提取物和山茱萸提取物。本研究结果表明,家蚕的本土食用植物具有抗氧化和抗菌作用,为开发新型猪疾病的草药药物铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Analysis of Natural Bioactive Metabolites of the Indigenous Host Plants of Muga Silkworm for Antioxidant and Antibacterial Properties against Swine Diseases
The present study explores the natural bioactive metabolites, antioxidant and antibacterial activities present in the host plants of Antheraea assamensis (muga silkworm) viz . Machilus bombycina (som), Litsea polyantha (sualu), Litsea salicifolia (dighloti) and Litsea citrata (mejankari). The methanolic extracts of leaves of these plants were screened for their phytochemical analysis and free radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl as the free radical. Phytochemical analysis revealed the presence of flavonoids, phenolic compounds, carotenoids, saponins, coumarins, terpenoids, tanins, cardiac glucosides and xanthoproteins in the said plants. The results of 2,2-diphenyl-1-picrylhydrazyl scavenging activity revealed Litsea polyantha to exhibit stronger antioxidant efficiency compared to the rest. Besides these, the plant extracts were investigated for their antibacterial assessment against Gram-positive Staphylococcus aureus and Streptococcus suis and Gram-negative Pasteurella multocida and Escherichia coli bacteria found in pig. All the plant extracts were validated to possess antibacterial activity with variable potency. Litsea citrata was the most effective extract retarding microbial growth of both Gram-positive and Gram-negative bacteria, followed by Litsea salicifolia , Litsea polyantha and Machilus bombycina . The present findings underscore the fact that indigenous food plants of muga silkworm are fortified with antioxidant and antibacterial efficiency, which might pave to the development of novel herbal pharmacological compounds for the medication of pig diseases.
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来源期刊
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审稿时长
2 months
期刊介绍: The Indian Journal of Pharmaceutical Sciences (IJPS) is a bi-monthly Journal, which publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences (Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Therapeutics, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmacovigilance, Pharmacoepidemiology, Pharmacoeconomics, Drug Information, Patient Counselling, Adverse Drug Reactions Monitoring, Medication Errors, Medication Optimization, Medication Therapy Management, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on current topics in Pharmaceutical Sciences are also considered for publication by the Journal.
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