免疫系统历经岁月

IF 0.9 Q4 IMMUNOLOGY
K. Rosenthal, Jordan B. Baker
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引用次数: 1

摘要

免疫系统的组成部分在子宫内发育,就像电脑一样,一些组成部分立即起作用(先天组成部分),但其他组成部分必须学习功能所需的程序和细节(抗原适应组成部分)。像其他系统一样,包括军事和市政,先天和抗原特异性成分发展成一个免疫系统,帮助维持和监视其他身体过程和系统的畸变,提供监视和保护粘膜上皮边界和保护免受微生物入侵。这些过程中的无能、过度或错误会导致疾病。免疫系统的衰老带来免疫衰老、炎症、更多错误和监测减少,从而增加新感染(如COVID-19、流感)、潜伏感染、癌症、自身免疫性和炎症性疾病复发的风险。随着对衰老的监测、效应和调控缺陷的更深入了解,可以开发出更好的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The immune system through the ages
The components of the immune system develop in utero and like a computer, some components are immediately functional (the innate components) but other components must learn the programs and details necessary to function (antigen adaptive components). Like other systems, including military and municipal, the innate and antigen specific components develop into an immune system that helps maintain and surveil the other body processes and systems for aberrations, provide surveillance and protection of the mucoepithelial borders and protection from microbial invasion. Inability, excesses, or errors in these processes cause disease. Aging of the immune system brings immunosenescence, inflammaging, more errors, and decreased surveillance which increases risk for new infections (e.g. COVID-19, influenza), recurrence of latent infections, cancer and autoimmune and inflammatory diseases. With greater understanding of the surveillance, effector and regulatory deficits upon aging, better therapies can be developed.
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