对抗磷酸奥司他韦对癫痫易感小鼠脑电图改变的措施

Q4 Medicine

Epilepsy and Seizure Pub Date : 2012-01-01 DOI:10.3805/EANDS.5.20

Y. Kawakami, Kenichi Saito, Asami Baba, Shinya Koizumi, K. Kuwabara, T. Fujita, O. Fujino

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引用次数: 0

摘要

据报道，磷酸奥司他韦可以改变癫痫易感El小鼠脑电图(EEGs)的峰值放电。目前的研究表明，两种抗癫痫药物(丙戊酸钠和地西泮)可以抵消这种改变。我们的观察结果表明，当有癫痫倾向但没有服用常规抗癫痫药物的患者服用磷酸奥司他韦时，短期补充丙戊酸钠或地西泮可作为一种选择。摘要

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Measures to Counteract Oseltamivir Phosphate-Induced Changes on Electroencephalograms of Epilepsy-Prone El Mice

Oseltamivir phosphate has been reported to change spike discharges on electroencephalograms (EEGs) of epilepsy-prone El mice. The present study shows that two anti-epileptic drugs (sodium valproate and diazepam) counteract such alterations. Our observations sug-gest that short-term supplemental administration of sodium valproate or diazepam may be considered as an option when patients with epileptic tendencies but are not on a regular course of anti-epileptic drugs are taking oseltamivir phosphate. Abstract

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来源期刊

Epilepsy and Seizure Medicine-Neurology (clinical)

CiteScore

1.30

自引率

0.00%

发文量