单核苷酸多态性与阿尔茨海默病

中华老年多器官疾病杂志 Pub Date : 2011-01-01 DOI:10.3724/sp.j.1264.2011.00023

Zhong Yuan

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引用次数: 0

摘要

遗传因素在阿尔茨海默病(AD)的发展中起着重要作用。我们主要介绍了近年来报道的一些易致AD不同方面的基因。此外，我们还从表观遗传学、基因或药物治疗等方面探讨了如何阻断一些易感基因的表达途径，从而抑制或延缓AD的发展。除了一些与家族性AD和载脂蛋白E相关的基因外，其他一些与散发性AD相关的易感基因仍有争议。种族多样性和样本量可以解释不同研究的分歧。因此，需要进一步的研究来更好的诊断和基因治疗AD。

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Single nucleotide polymorphism and Alzheimer's disease

Genetic factors play important roles in the development of Alzheimer's disease(AD).We mainly introduced some genes, which has been reported in recent years,predisposing to different aspects of AD.Besides,from the aspects of epigenetics,gene or drug therapy,we also discussed how to block the expression pathway of some predisposing genes,so as to inhibit or delay the development of AD.Except several genes related to familial AD and apolipoprotein E,some other predisposing genes related to sporadic AD remains controversal.Racial diversity and sample size might explain the disagreement of various researches.Therefore,further studies are needed for better diagnosis and gene therapy of AD.

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来源期刊

中华老年多器官疾病杂志

自引率

0.00%

发文量

3039

期刊介绍： Chinese Journal of Multiple Organ Diseases in the Elderly (monthly) is a medical academic journal under the supervision of PLA General Hospital, sponsored by PLA General Hospital Medical Innovation Research Department, National Clinical Medical Research Center for Geriatric Diseases (PLA General Hospital), and Department of Cardiovascular Medicine of the Sixth Medical Center of PLA General Hospital, and publicly issued at home and abroad. This journal was founded in June 2002 and is a Chinese Science and Technology Paper Statistical Source Journal (China Science and Technology Core Journal), and is included in major domestic retrieval systems and well-known domestic and foreign retrieval systems such as the American Chemical Abstracts. As the only academic journal in China that reflects multi-organ diseases in the elderly, Chinese Journal of Multiple Organ Diseases in the Elderly mainly exchanges the diagnosis and treatment experience and lessons of cardiovascular diseases in the elderly, especially cardiovascular diseases in the elderly combined with other diseases, diseases of more than two organs in the elderly, and other multiple diseases in the elderly, explores their pathogenesis and effective diagnosis and treatment measures, and focuses on reporting the latest clinical, basic and preventive achievements and experiences in the research of the above diseases in my country with innovative significance; the main readers are medical, scientific research and teaching personnel engaged in geriatric cardiology and (or) geriatric medicine and related diseases. The main columns include expert comments, special forums, clinical research, basic research, clinical pharmacy, case reports, new technologies and methods, clinical pathology discussions, reviews, academic trends, expert popular science lectures, etc.