{"title":"缬沙坦与氨氯地平对原发性高血压患者血浆Apelin-12影响的比较研究","authors":"Shifang Wang, Juan-ling Wang, Tong-xiang Liu","doi":"10.3760/CMA.J.ISSN1673-8799.2010.12.40","DOIUrl":null,"url":null,"abstract":"Objective To study the effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension. Methods The 110 mild and moderate hypertension patients were divided randomly into 2 groups, 58 patients were treated in valsartan, 52 patients were treated in amlodipine. 50 healthy people physical examinded were control group. All the cases were detected Apelin-12. After 16 weeks' anti-hypertensine lowering with valsartan and amlodipine for EH group, the above item was detected again. Results The plasma Apelin-12 level after treatment of valsartan and amlodipine was significantly higher than that of treatment before. The plasma Apelin-12 level after treatment of valsartan was significantly higher than that of treatment of amlodipine. Conclusion Valsartan increase plasma Apelin-12 more than amlodipine. \n \nKey words: \nHypertension; Apelin-12; valsartan; Amlodipine","PeriodicalId":64135,"journal":{"name":"中国临床实用医学","volume":"4 1","pages":"74-75"},"PeriodicalIF":0.0000,"publicationDate":"2010-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative study to effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension\",\"authors\":\"Shifang Wang, Juan-ling Wang, Tong-xiang Liu\",\"doi\":\"10.3760/CMA.J.ISSN1673-8799.2010.12.40\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective To study the effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension. Methods The 110 mild and moderate hypertension patients were divided randomly into 2 groups, 58 patients were treated in valsartan, 52 patients were treated in amlodipine. 50 healthy people physical examinded were control group. All the cases were detected Apelin-12. After 16 weeks' anti-hypertensine lowering with valsartan and amlodipine for EH group, the above item was detected again. Results The plasma Apelin-12 level after treatment of valsartan and amlodipine was significantly higher than that of treatment before. The plasma Apelin-12 level after treatment of valsartan was significantly higher than that of treatment of amlodipine. Conclusion Valsartan increase plasma Apelin-12 more than amlodipine. \\n \\nKey words: \\nHypertension; Apelin-12; valsartan; Amlodipine\",\"PeriodicalId\":64135,\"journal\":{\"name\":\"中国临床实用医学\",\"volume\":\"4 1\",\"pages\":\"74-75\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2010-12-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中国临床实用医学\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN1673-8799.2010.12.40\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国临床实用医学","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN1673-8799.2010.12.40","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparative study to effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension
Objective To study the effect of valsartan and amlodipine on plasma Apelin-12 in patients with essential hypertension. Methods The 110 mild and moderate hypertension patients were divided randomly into 2 groups, 58 patients were treated in valsartan, 52 patients were treated in amlodipine. 50 healthy people physical examinded were control group. All the cases were detected Apelin-12. After 16 weeks' anti-hypertensine lowering with valsartan and amlodipine for EH group, the above item was detected again. Results The plasma Apelin-12 level after treatment of valsartan and amlodipine was significantly higher than that of treatment before. The plasma Apelin-12 level after treatment of valsartan was significantly higher than that of treatment of amlodipine. Conclusion Valsartan increase plasma Apelin-12 more than amlodipine.
Key words:
Hypertension; Apelin-12; valsartan; Amlodipine