近交系小鼠对结核感染的易感性随表型、感染剂量、肥胖和肠道微生物组成而变化

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2021-01-01 DOI:10.35248/2161-1068.21.11.284

S. Kayukova, A. Donnikov, I. Bocharova, B. Nikonenko

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引用次数: 1

摘要

在这项工作中，我们进行了对结核感染不同敏感性、I/St易感、C57BL/6耐药的近交系小鼠的比较研究。另外两个菌株C3H。JK (H2j)、C3H/HeDiSn (H2k)在4-5月龄时开始长脂，并根据感染剂量改变易感性。此外，它们的肥胖与否取决于感染的剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Inbred Mouse Strain Susceptibility to Tuberculosis Infection Vary with Phenotype, the Dose of Infection, Obesity and Composition of the Intestinal Microbiome

In this work, we conducted comparative studies of inbred mice with different sensitivity to tuberculosis infection, I/St susceptible, C57BL/6 resistant. Two other strains C3H.JK (H2j), C3H/HeDiSn (H2k) began to grow fat by 4-5 months of age and changed their susceptibility depending on the dose of infection. Also, they were made obese or not in dependence on the dose of infection.

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Mycobacterial diseases : tuberculosis & leprosy

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