焦亡在骨髓发育不良综合征发病机制中的研究进展

国际输血及血液学杂志 Pub Date : 2018-11-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2018.06.014

C. Ling, Qi-Chuan Jin, W. Gong, Qi-guo Zhang

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引用次数: 0

摘要

焦亡是由炎性半胱氨酸-天冬氨酸蛋白酶(Caspase)介导的程序性细胞死亡。细胞间或细胞外病原体可通过激活Caspase-1、Caspase-4/5/11、IL -1β和IL-18促进炎症的形成。被激活的炎性因子导致细胞裂解和炎性因子释放，最终诱导细胞死亡。Toll样受体(Toll like receptor, TLR)信号通路和骨微环境的改变以及炎性小体的存在可引起炎症环境的形成，从而导致骨髓增生综合征(myelelodyplastic syndrome, MDS)。本文就热亡的发生机制及热亡与MDS的关系作一综述。关键词:焦亡;Myelodyplastic综合症;还存在;Interleukin-1beta;Interleukin-18

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Research progress on role of pyroptosis in pathogenesis of myelodyplastic syndrome

Pyroptosis is the programmed cell death mediated by inflammatory cysteine-aspartic protease (Caspase). Intercallular or extracellular pathogens can promote the formation of inflammatory by activating Caspase-1, Caspase-4/5/11, pro-interleukin (IL)-1β and pro-IL-18. The activated inflammatory cytokines lead to cell lysis and inflammatory factors release, and finally induced cell death.The alterations of Toll like receptor(TLR) signaling pathway and bone microenvironment, and presence of inflammasome could cause the formation of an inflammatory environment, leading to myelodyplastic syndrome (MDS). The article reviews the mechanism of pyroptosis and the relationship between pyroptosis and MDS. Key words: Pyroptosis; Myelodyplastic syndrome; Caspases; Interleukin-1beta; Interleukin-18

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.