Studies on the permeability to lipids and lipoproteins of inflamed skin capillaries.

Abstract : Lipids and lipoproteins were filtered with different negative pressures through the base of cantharidine blisters. With an increase of the vacuum there was a decrease of the concentration of all lipid classes, but the total amount of filtrated lipids was elevated. The permeability was most restricted to cholesterol and cholesterol esters. We concluded that with an increase in blood pressure there will be an increased deposition of cholesterol in the wall of the blood vessels. This will be one predominant factor in atherosclerosis.