白细胞阻滞:β2整合素活化的生物力学和分子机制。

IF 1 4区医学 Q4 BIOPHYSICS

Biorheology Pub Date : 2016-02-10 DOI:10.3233/BIR-15085

Zhichao Fan, K. Ley

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引用次数: 37

摘要

整合素是一组异二聚体跨膜受体，在细胞-细胞和细胞-基质相互作用中起重要作用。整合素在许多生理过程和疾病中起重要作用。整合素通过被称为活化的分子构象变化获得与其配体的亲和力。本文综述了整合素构象变化过程中的分子生物力学、整合素在白细胞生物流变中的功能(在滚动和阻滞过程中的粘附功能)以及整合素激活过程中涉及的分子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation.

Integrins are a group of heterodimeric transmembrane receptors that play essential roles in cell-cell and cell-matrix interaction. Integrins are important in many physiological processes and diseases. Integrins acquire affinity to their ligand by undergoing molecular conformational changes called activation. Here we review the molecular biomechanics during conformational changes of integrins, integrin functions in leukocyte biorheology (adhesive functions during rolling and arrest) and molecules involved in integrin activation.

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来源期刊

Biorheology 医学-工程：生物医学

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biorheology is an international interdisciplinary journal that publishes research on the deformation and flow properties of biological systems or materials. It is the aim of the editors and publishers of Biorheology to bring together contributions from those working in various fields of biorheological research from all over the world. A diverse editorial board with broad international representation provides guidance and expertise in wide-ranging applications of rheological methods to biological systems and materials. The scope of papers solicited by Biorheology extends to systems at different levels of organization that have never been studied before, or, if studied previously, have either never been analyzed in terms of their rheological properties or have not been studied from the point of view of the rheological matching between their structural and functional properties. This biorheological approach applies in particular to molecular studies where changes of physical properties and conformation are investigated without reference to how the process actually takes place, how the forces generated are matched to the properties of the structures and environment concerned, proper time scales, or what structures or strength of structures are required.