海洋来源真菌鹿角曲霉GXIMD00519的次生代谢物

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2022-10-29 DOI:10.25135/rnp.355.2207.2518

Xinya Xu, Chun-Ju Lu, Zhenzhou Tang, Y. Liu, Cheng-Hai Gao, Haiyan Li, Ge Zhang, Zhi-wei Su

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引用次数: 0

摘要

从海洋源真菌carneusus Aspergillus GXIMD00519中分离得到2个新化合物carneusins A-B(1-2)和15个已知化合物(3-17)。通过详细的光谱数据分析和量子化学计算，阐明了它们的结构。对所有化合物的抗菌、抗生物膜和细胞毒作用进行了评价。化合物1对MRSA具有中等抑制作用，MIC值为32µg/mL。化合物2对生物污染细菌轮氏弧菌和巨形异单胞菌具有抗微污染作用，MIC值为64µg/mL。化合物5具有抗虫活性，ec50值为10.42±0.58µg/mL。化合物1、3、4、8和15对人胰腺癌细胞株SW1990、结直肠癌细胞株DLD1、人胰腺癌细胞株PANC1和人肝癌细胞株Bel7402具有细胞毒性，ic50值为2.75 ~ 17.77µM。

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Secondary Metabolites from Marine-Derived Fungus Aspergillus carneus GXIMD00519

: Two new compounds, carneusins A-B ( 1-2 ), as well as fifteen known compounds ( 3-17 ), were isolated from the marine-derived fungus Aspergillus carneus GXIMD00519. Their structures were elucidated by the analysis of detailed spectroscopic data and quantum chemistry calculations. All the compounds were evaluated for their antibacterial, antibiofilm and cytotoxic effects. Compound 1 showed a moderate inhibitory effect against MRSA with the MIC value of 32 µg/mL. Compound 2 exhibited an anti-microfouling effect against biofouling bacterial Vibrio rotiferianus and Alteromonas macleodii with MIC value of 64 µg/mL. Compound 5 displayed antibiofilm activity against A. macleodii with the EC 50 value of 10.42 ± 0.58 µg/mL. Compounds 1 , 3 , 4 , 8 and 15 showed cytotoxicity against human pancreatic cancer cell lines SW1990, colorectal adenocarcinoma cell line DLD1, human pancreatic cancer cell line PANC1, and human hepatocellular carcinoma cell line Bel7402 with IC 50 values ranging of 2.75-17.77 µM.

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来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.