The Use of ACTH Gel in Membranous Nephropathy

Membranous Nephropathy (MN) is one of the most common causes of nephrotic syndrome characterized by insidious onset, nephrotic range proteinuria, reduced renal function, and can lead to end stage renal disease. Treatment regimens for MN have been described including steroids treatment in combination with cyclophosphamide or calcineurin inhibitors, cyclosporine or tacrolimus. Adrenocorticotropin (ACTH) has been increasingly studied for various glomerulopathies, most notably MN and growing evidence suggesting that ACTH maybe an effective treatment option.