对氨基苯酰胺钴、镍金属配合物的抗真菌和抗氧化活性

IF 0.5 Q4 EDUCATION & EDUCATIONAL RESEARCH

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI:10.31788/rjc.2023.1628384

S. Narashimhavarman, K. Rajasekar, R. Selvarani, P. Chakkaravarthy, C. Veeravel, P. Sudhakar

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引用次数: 0

摘要

以对氨基苯甲酰胺和硫氰酸盐离子为原料，以等摩尔比合成钴镍生物活性金属螯合物，并对其电导率、紫外-可见、红外和远红外光谱以及金属离子估计鉴定进行了评价。根据配合物的光谱和磁特性，给出了配合物的八面体几何形状。这些配合物是顺磁性的、单体的和非电解质的。采用琼脂盘扩散法，以氟康唑为参比药物，通过体外机制比较金属螯合物与对氨基苯甲酰胺对白色念珠菌的抑菌活性。测定了金属螯合物体外清除DPPH自由基的能力，并与标准抗坏血酸进行了对比。根据四种不同浓度下IC50值的计算结果，这些复合物似乎具有中等活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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ANTIFUNGAL AND ANTIOXIDANT ACTIVITIES OF COBALT AND NICKEL METAL COMPLEXES OF P-AMINO BENZAMIDE

Cobalt and nickel bio-active metal chelates were synthesized using p-aminobenzamide and thiocyanate ion in an equimolar ratio, and they were assessed for conductivity, UV-Visible, IR, and far-IR spectra as well as metal ion estimation identification. Based on their spectral and magnetic characteristics, the complexes were given octahedral geometry. The complexes are paramagnetic, monomeric, and non-electrolyte. With the help of the Agar Disc diffusion method using fluconazole as the reference drug, the antifungal activity of metal chelates through an in-vitro mechanism was compared with p-aminobenzamide against C. albicans. Metal(II) chelates' in-vitro DPPH free radical scavenging ability was tested and contrasted with that of standard ascorbic acid. The complexes appear to have moderate activity, according to the results of the computation of the IC50 values at four distinct concentrations.

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来源期刊

Rasayan Journal of Chemistry Energy-Energy (all)

CiteScore

1.90

自引率

0.00%

发文量

196

期刊介绍： RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.