S. Elsirgany, H. Badawi, Z. El-khayat, M. Bibers, M. Hamdy, A. Hamdy, S. Salama, Rehab A. Lotfy, M. Alalfy
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引用次数: 5
摘要
目的:胎儿素a是一种存在于血液循环中的糖蛋白，可能与胰岛素抵抗和多囊卵巢综合征(PCOS)有关。我们研究的目的是探讨胎儿素a水平的变化作为多囊卵巢综合征患者可能的标志物。方法:本研究共纳入80名女性。A组:40名患有多囊卵巢综合征的女性代表该研究组，而另外40名月经规律且无高雄激素血症症状的女性代表对照组(B组)。测量两组的胎儿激素A水平以比较该激素水平。结果:PCOS组Fetuin A浓度较对照组升高(mean±SD: 521±7.1 vs 505±50.5 ng/ml)，差异有统计学意义。结论:胎儿素A水平可作为PCOS筛查指标，临界值为515 ng/ ml，敏感性为100%，特异性为45%。
Serum Fetuin a Level: A New Possible Marker for Polycystic Ovarian Syndrome in Women with Infertility
Objective: Fetuin-A is a glycoprotein which is present in circulation that might be linked to insulin resistance and polycystic ovary syndrome (PCOS). The aim of our study was to investigate the changes in Fetuin-A levels as a possible marker in patients with PCOS. Methods: In this study we included a total of 80 women. Group A;40 women with PCOS represented this study group, while another 40 women with regular cycles and no symptoms of hyperandrogenemia represented the controls(Group B). Fetuin-A level was measured in both groups to compare the level of this hormone. Results: Our results showed that Fetuin A concentration in the PCOS group was elevated than the control group (mean ± SD: 521 ± 7.1 vs 505 ± 50.5 ng/ml respectively) and the difference was statistically significant. Conclusions: Fetuin A level could be proposed as a screening test for PCOS with a cutoff value of 515 ng/ ml, the sensitivity and specificity were one hundred % and forty five %, respectively.
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