实验鼠类不同脑区神经元和胶质细胞线粒体的结构和功能特征

Q4 Medicine

Clinical and Experimental Morphology Pub Date : 2022-01-01 DOI:10.31088/cem2023.12.2.5-13

A. Egorova, D. Voronkov, E. Fedorova, T. I. Baranich, V. Glinkina, V. Sukhorukov

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引用次数: 0

摘要

本文综述了啮齿类动物不同脑结构中神经元和神经胶质细胞线粒体形态和功能的最新研究资料。我们讨论了神经元线粒体细胞内和区域异质性的主要方面。强调了不同脑区线粒体的功能差异。我们分析了脑胶质细胞中线粒体的结构和功能特征，以及它们在维持胶质神经元相互作用中的作用。本文介绍了线粒体细胞间转运作为一种新的神经保护机制的可能性的最新信息，说明了星形细胞-神经元网络的功能。了解不同脑区线粒体的结构和功能特征可能有助于确定线粒体疾病的药理靶点和制定新的治疗策略。关键词:线粒体，神经元，胶质细胞，胶质-神经元相互作用

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Structural and functional features of mitochondria in neurons and gliocytes of various cerebral regions of laboratory rodents

This review considers modern data on the morphology and functions of mitochondria in the neurons and glial cells in various brain structures of laboratory rodents. We discuss the main aspects of intracellular and regional heterogeneity of neuronal mitochondria. The functional differences between mitochondria in different cerebral regions are highlighted. We analyze the structural and functional features of mitochondria in brain gliocytes as well as their role in maintaining glioneuronal interactions. The article presents the latest information on the possibilities of intercellular transportation of mitochondria as a new neuroprotective mechanism illustrated on the functioning of astrocyte-neuron networks. Understanding the structural and functional features of mitochondria in different brain areas may help identify pharmacological targets and develop new strategies for mitochondrial disease management. Keywords: mitochondria, neurons, gliocytes, glio-neuronal interaction

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来源期刊

Clinical and Experimental Morphology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

0.60

自引率

0.00%

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