重组人绒毛膜促性腺激素治疗疑似黄体功能不全的母狗卵巢过度刺激综合征1例报告

IF 0.6 4区 农林科学 Q3 VETERINARY SCIENCES
E. Cigánková, R. Vitásek, K. Jelinkova
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引用次数: 0

摘要

本文采用重组人绒毛膜促性腺激素(r-hCG)治疗2只有低类睾酮病史的母狗,治疗时间为发情早期。黄体酮水平升高,但治疗导致卵巢过度刺激,导致卵巢过度刺激综合征(OHSS),随后发展为雌激素毒性。这是第一个记录狗在服用r-hCG后出现OHSS的病例。虽然在我们的病例报告中表现为在发情期,但OHSS的发生与女性使用类似的r-hCG有关。所描述的使用促性腺激素不适合治疗黄体功能不全,但由于其惊人的效果,似乎在辅助生殖技术中占有一席之地。由于这些不可预测的结果,对母狗黄体营养因子的进一步研究是必要的。为了获得更好的结果,需要考虑降低剂量和给药频率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ovarian hyperstimulation syndrome in a bitch caused by recombinant human chorionic gonadotropin treatment of suspected luteal insufficiency – a case report
Two bitches with a history of hypoluteoidism were treated by recombinant human chorionic gonadotropin (r-hCG) in repeated doses during early dioestrus. The level of progesterone increased, but the therapy led to hyperstimulation of the ovaries which resulted in ovarian hyperstimulation syndrome (OHSS), with subsequent development of oestrogen toxicity. This is the first case documenting OHSS in a canine after administration of r-hCG. Although manifested during dioestrus in our case report, the occurrence of OHSS is associated with similar administration of r-hCG to women. The described use of r-hCG is not appropriate for luteal insufficiency treatment, but seems to have a place in assisted reproduction technology because of its surprising effects. Further research of luteotrophic factors in bitches is warranted because of these unpredictable results. Lower doses and frequency of administration need to be considered for a better outcome.
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来源期刊
Acta Veterinaria Brno
Acta Veterinaria Brno 农林科学-兽医学
CiteScore
1.00
自引率
33.30%
发文量
36
审稿时长
18-36 weeks
期刊介绍: ACTA VETERINARIA BRNO is a scientific journal of the University of Veterinary and Pharmaceutical Sciences in Brno, Czech Republic. The scientific journal Acta Veterinaria Brno is dedicated to the publication of original research findings and clinical observations in veterinary and biomedical sciences. Original scientific research articles reporting new and substantial contribution to veterinary science and original methods that have not been submitted for publication elsewhere are considered for publication. A written statement to this effect should accompany the manuscript, along with approval for publication by the author´s head of department. The authors bear full responsibility for the contents of their contribution. Book reviews are published, too.
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